General Information of DME (ID: DME0094)
DME Name Metallothionein-1A (MT1A), Homo sapiens
Synonyms Metallothionein-IA; MT-1A; MT-IA; MT1A; MT1S; OMIM: 156350; GeneCards: MT1A
Gene Name MT1A
UniProt ID
MT1A_HUMAN
Gene ID
4489
EC Number    EC: 1.8.5.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Sulfur donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.8.5.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
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       Interactions between Microbiome and DME (MICBIO)                       
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCC
A
Pathway Mineral absorption (hsa04978 )
Function This enzyme acts as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          3 Drugs
Cisplatin
Drug Info Approved Lung cancer ICD11: 2C25 [1]
Oxaliplatin
Drug Info Approved Colorectal cancer ICD11: 2B91 [2]
Carboplatin
Drug Info Approved Ovarian cancer ICD11: 2C73 [2]
References
1 Role of metallothionein in cisplatin sensitivity of germ-cell tumours. Int J Cancer. 2000 Mar 15;85(6):777-81.
2 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)

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