| General Information of DME (ID: DME0255) |
| DME Name |
Acyl-CoA thioesterase 2 (ACOT2), Homo sapiens
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| Synonyms |
Acyl-coenzyme A thioester hydrolase 2a; Acyl-coenzyme A thioesterase 2, mitochondrial; CTE-Ia; Long-chain acyl-CoA thioesterase 2; ACOT2; PTE2; PTE2A; ZAP128
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| Gene Name |
ACOT2
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 3.1.2.2 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Thioester hydrolase
EC: 3.1.2.2
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Microbiome and DME (MICBIO)  Jump to Detailed Interactome Data  |
Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Sequence |
MSNKLLSPHPHSVVLRSEFKMASSPAVLRASRLYQWSLKSSAQFLGSPQLRQVGQIIRVP
ARMAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLG
ELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGR
LLCQTRHERYFLPPGVRREPVRVGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLL
AGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHPEVKGPGVGLLGISKGGELC
LSMASFLKGITAAVVINGSVANVGGTLHYKGETLPPVGVNRNRIKVTKDGYADIVDVLNS
PLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPET
GHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIP
SKV
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| Structure |
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| Pathway |
Biosynthesis of unsaturated fatty acids (hsa01040 ) |
| Fatty acid elongation (hsa00062 ) |
| Metabolic pathways (hsa01100 ) |
| Ovarian steroidogenesis (hsa04913 ) |
| Function |
This enzyme catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. It displays higher activity toward long chain acyl CoAs (C14-C20). And it is involved in enhancing the hepatic fatty acid oxidation in mitochondria.
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