Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1028)
DME Name Chloramphenicolase (chlR), Escherichia coli
Synonyms Chloramphenicol reductase; Enzyme chloramphenicolase; Reductase chloramphenicol
Gene Name chlR
UniProt ID
A0A5M4B0P0_9BACT
EC Number    EC: 2.3.1.28     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.28
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKIDLNSWNRREHFAFFSQFDEPFFSIVAEVDCTVAYRKAKEQDIPFFIWYLYQSLLAA
NQVEPFRYRIIDNEVVVLDEIHASSTVAREDHTFGFTFMPYREDIKAFVAEALPEIERVQ
QLEGLCFDEKTSRTDVIHYSSIPWINFTALTHARHNARKDSVPKISFGQYQEKEGKLMMP
VSVTVHHGLMDGYHVGLFLTKFQKLLES
Function This enzyme catalyzes the hydrolysis of the amide bond in chloramphenicol.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Chloramphenicol
 Drug Info Approved Conjunctivitis ICD11: 9A60 [1]
References
1 The bacterial degradation of chloramphenico. Lancet. 1967 Jun 10;1(7502):1259-60.

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