Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1058)
DME Name Propanediol dehydrogenase (dhaT), Lactobacillus brevis
Synonyms Dehydrogenase propanediol; 1,3-propanediol dehydrogenase; 13-propanediol dehydrogenase; AZI11_12055; CCS05_11470; CNR29_12615; LbDm2_1760; NCTC13386_00196; UCCLBBS449_2334; dhaT
Gene Name dhaT
UniProt ID
A0A0C1Q6R1_LACBR
Gene ID
4413383
EC Number    EC: 1.1.1.202     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.202
Lineage    Species: Lactobacillus brevis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus brevis
Subspecies: Lactobacillus brevis 6239
Subspecies: Lactobacillus brevis B22
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MAERSYDFLMPSVNFFGPGVISKIGDRAKMLGMKKPVIVTDKFLEGLKDGAVEQTLDSLK
AAGVDYVVYNNVEPNPKIRNIKEVKKLYEESGADSIITVGGGSAHDTGKGAGIILTNGDD
ITKLAGIETLDKALPPLIAVNTTAGTGSELTRHAVITNEETHLKFVVVSWRNIPLVSFND
PTLMLDVPKGLTAATGMDAFVQAVEPYVSVDHNPITDSQCVEAIKLIETSLREAVANGHN
LDARTKMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNIIAC
PDRFAQLAEIMGENTEGLSTRDAAELAIKAMKQLSEDVGIPHSIKEIGAKPEDFELMAEN
ALKDGNAFSNPRKGTKEDIIKIFQAAYDAE
Function This enzyme uses NAD+ to oxidize 1,3-propanediol, glycerol, ethanol and 1,2-propanediol. This enzyme required Mn2+ and are probably octamers with a molecular mass of 350 kDa.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Glycerol
 Drug Info Approved Hepatic encephalopathy ICD11: DB99 [1]
References
1 Expression and characterization of a novel 1,3-propanediol dehydrogenase from Lactobacillus brevis. Appl Biochem Biotechnol. 2016 Jul;179(6):959-72.

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