Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1070)
DME Name Nitroreductase (NTR), Clostridium leptum
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; DWW99_07865
Gene Name NTR
UniProt ID
A0A412R9E4_9FIRM
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Clostridium leptum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Clostridium
Species: Clostridium leptum
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKITEALKARRSYYAINRELPVAIDRVMDMVKELTELVPDAFNMKSSRVAVVHGEKQDQL
WNKIYDVFEGKVAREKIDSFRAGSGTILYFYDRKVVESLQKQYPLYADNFPVWASQSSAM
LQLAVWSGLRELNIGASLQHYNPVIDNAVKELLHLSGDYVLVAEMPFGGIVEEPAPKDKE
EIEKRVFSAC
Function This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrofurantoin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrazepam
 Drug Info Phase 3 Insomnia ICD11: 7A00 [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
P-nitrobenzoic acid
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.
2 Reduction of nitrazepam by Clostridium leptum, a nitroreductase-producing bacterium isolated from the human intestinal tract. Clin Infect Dis. 1997 Sep;25 Suppl 2:S121-2.

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