Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1123)
DME Name Glutamate racemase (MurI), Lactobacillus fermentum
Synonyms D-glutamate racemase; MurI; murI; BAS0806; BAS4379; BcGR; BsGR; BsRacE; DapF; FnGR; GBAA_0847; GBAA_4717
Gene Name murI
UniProt ID
MURI_LACFE
Gene ID
6233637
EC Number    EC: 5.1.1.3     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Amino acid racemase/epimerase
EC: 5.1.1.3
Lineage    Species: Lactobacillus fermentum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus fermentum
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MDNRPIGVMDSGLGGLSVVRVIQQKLPNEEVIFVGDQGHFPYGTKDQAEVRQLALSIGAF
LLKHDVKMMVVACNTATAAALPALQAALPIPVIGVIEPGARAALAQDKKGPIGVIATTAT
TTAGAYPATIERLAPGTPVIAKATQPMVEIVEHGQTGTAKAQEVVSEQLMTFKEHPVKTL
IMGCTHFPFLAPEISKAVGPTVALVDPAKETVATAKSWLEQHQAMGNHAHPNYHLYSTGN
LPDLRAGVNKWLLSGHFDLGTAQIEEGD
Function This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamine.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-glutamine
 Drug Info Approved Sickle-cell anaemia ICD11: 3A51 [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
L-glutamine
 Drug Info Approved Sickle-cell anaemia Km = 330 microM [1]
References
1 Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. J Mol Biol. 2007 Aug 31;371(5):1219-37.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.