Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1133)
DME Name Cellobiose 2-epimerase (CE), Eubacterium cellulosolvens
Synonyms Cellobiose epimerase; CS-HRCE; Caob-CE; B15CE; BfCE; CE; CE-NE1; CsCE; ce13
Gene Name ce13
UniProt ID
CEEP_EUBCE
EC Number    EC: 5.1.3.11     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Carbohydrate racemase/epimerase
EC: 5.1.3.11
Lineage    Species: Eubacterium cellulosolvens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Eubacteriaceae
Genus: Eubacterium
Species: Eubacterium cellulosolvens
Subspecies: Eubacterium cellulosolvens NE13
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKNEVVYKQLTEKILPFWNAMRDDENGGFYGYMSEDLHIDDHADKGCILNSRILWFYSTA
YMYLQDEKLLDNAKHAFEFLKTYCFDPMCGGIFWSVRYNGKPADTTKHTYNQAFAIYALS
AYYEATGSIEAIAIAEIIYEKIEDTMRDTKGYLEAFTRDFRPADNDKLSENGVMAERTMN
TLLHIIEAYSALVHALRKKVADPAKGDVRDELFMNVVENKLAAALELMRDKFYNSDRHRL
DVFFDKEYESLIDLTSYGHDIEASWLLEWAAGILDDEEITESLHPISSDLVEKVYKEAFD
GHSIVNECEDGDVNTDRIWWVEAESVLGFLKAFEREGKEEYRKAAHEILAFILDKQVDKR
EGSEWFEMLKEDGTPCHKPMVREWKCPYHNGRMCLEILKSGIEIG
Function This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety. Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) and epimerizes lactose to epilactose.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
M-7403
 Drug Info Phase 1/2 Prostate cancer ICD11: 2C82 [1]
Lactose
 Drug Info Phase 1 Lactose intolerance ICD11: 5C61 [1]
References
1 Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.

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