Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1143)
DME Name Hyaluronidase (hyl), Bacillus megaterium
Synonyms Chondroitin sulfate hydrolase; Hyaluronate lyase; Chondroitinase; Chondroitinase I; Cumulase; HYase; hyl; hysA
Gene Name hyl
UniProt ID
W5RSC1_9BACI
EC Number    EC: 4.2.2.1     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-oxygen lyase
Polysaccharide-lyase
EC: 4.2.2.1
Lineage    Species: Bacillus megaterium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus megaterium
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
NESTLLLNTSFEETEAPKSGWDQLGAPKWGVWRPTGSPIVTITKEASRTGEYGLKIAAAQ
SARAAVSQDVPVQGGQTYQLGTWLKTDNIVSGQGARLRVVLYEGTQQLGLLYSSRLTGTH
DWSQIKMEVKTPANADSIRVQLFFETGTGTALFDDVSLQLIQPATSIAIEESEITIKEQE
TGLLHAQMVPADASSKVSWVSADPSIATVDNGKVTGVNPGGTTIMAFTDNGLAATSTVKV
IKNDGIERPEVTQLDLQPKELELGSGQVRLLQAIIAPATADAEKLVWSSSNEAVASIQKG
LIEAKASGTAVITVETEDGSLKSESQITVTDAVVDEYDQLRKKWKSLMTGLDSYDPTNVR
MNEMIQNQTKSAETLWKTMFKNNDRSFLWINFASTDNSADIRDSYRNLTTMAKAFANEHS
SLYRNPQLLKDITEALEWLYQNRYNESIAQYSNWWHWEIGVPNELNSLMVLLYDYLDQDS
IHRYLKVVDHFQPDPTKSGATTPEKYREALGANRIDVSKVVGVRGVIVKDATKIAAARDA
LSQTFENVTEGDGFYEDGSFVQHENIAYNGSYGIVLIEGLTDMLELLSNSTWQVTDPKVT
NVYDWIETAYEPFMYKGALMDMVRGRAISRNFLQDHQAGHTIIKSVIRMAQFAPEPYAEK
YNSMAKYWLQEDTYLDYFKNAGNFRDITLAKQLLEKQEVTPRGDLDFHKTFASMDRVVHR
KSGYAFGISMYSNRIQNYEDMNDENRKGWYTGEGMTYLYNGDLAQYSDDFWPTVDPYRMP
GTTVDTMRRADGSGEHRSSESWTGGSTLKNFGSAGMSYDAWNSSLIAKKSWFMFDNEIVA
LGAGITSSEDRNVESIVENRKIRNDGSNQLVINGETLNLSNGGQNQTMAAKWAFLEGNVP
GADIGYYFPEGKMLTIKKEERTGAWKDINYGGPAEAIKRSYTTMWFDHGVRPEQDTYSYV
LLPGLNKEQTHQYSQNPDITILRNDSAVQAVQDVKENIIGANFWKDEKQSAGPLTVYQKA
SVTMQEKDGVLEIAVCDPTMENKGSIEIEIDGKAFKVLEADESITVENTKPSIKLKVNVN
EAKGKTFTAKLKMIPSQKGNSPNSIR
Function This enzyme catalyzes the degradation of hyaluronan by a beta-elimination reaction and it also acts on chondroitin.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Hyaluronan
 Drug Info Phase 4 Osteoarthritis ICD11: FA00 [1], [2]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
Hyaluronan
 Drug Info Phase 4 Osteoarthritis Km = 20 microM [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR007239 Hyaluronan Unsaturated disaccharides Unclear - Unclear Hyaluronan [3]
References
1 A novel hyaluronidase produced by Bacillus sp. A50. PLoS One. 2014 Apr 15;9(4):e94156.
2 Intracellular oxidative damage due to antibiotics on gut bacteria reduced by glutathione oxidoreductase-derived antioxidant molecule GM15. Arch Microbiol. 2020 Feb 14.
3 A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069.

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