Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1154)
DME Name ATP-dependent 6-phosphofructokinase (pfkA), Lactobacillus delbrueckii
Synonyms Phosphofructokinase; Phosphohexokinase; Phosphohexokinase pfkA; pfkA; ATP-PFK
Gene Name pfkA
UniProt ID
PFKA_LACDE
Gene ID
4085048
EC Number    EC: 2.7.1.11     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.11
Lineage    Species: Lactobacillus delbrueckii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus delbrueckii
Subspecies: Lactobacillus delbrueckii subsp. bulgaricus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKRIGILTSGGDAPGMNAAVRAVTRVAIANGLEVFGIRYGFAGLVAGDIFPLESEDVAHL
INVSGTFLYSARYPEFAEEEGQLAGIEQLKKHGIDAVVVIGGDGSYHGALQLTRHGFNSI
GLPGTIDNDIPYTDATIGYDTACMTAMDAIDKIRDTASSHHRVFIVNVMGRNCGDIAMRV
GVACGADAIVIPERPYDVEEIANRLKQAQESGKDHGLVVVAEGVMTADQFMAELKKYGDF
DVRANVLGHMQRGGTPTVSDRVLASKLGSEAVHLLLEGKGGLAVGIENGKVTSHDILDLF
DESHRGDYDLLKLNADLSR
Structure
1ZXX
Function This enzyme catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Fructose 6-phosphate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Purification and properties of the phosphofructokinase from Lactobacillus bulgaricus. A non-allosteric analog of the enzyme from Escherichia coli. Eur J Biochem. 1991 Jun 15;198(3):683-7.

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