Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1162)
DME Name Beta-fructofuranosidase (BFRU), Bifidobacterium longum
Synonyms Sucrose-6-phosphate hydrolase; Invertase; Glycoside hydrolase family 32 protein; DPC6316_1322; DWV93_02555
Gene Name cscA
UniProt ID
E1CPU3_BIFLN
EC Number    EC: 3.2.1.26     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.26
Lineage    Species: Bifidobacterium longum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium longum
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MTDFTPETPVLTPIRDHAAELAKAEAGVAEMAAKRNNRWYPKYHIASNGGWINDPNGLCF
YKGLWHVFYQLHPYGTQWGPMHWGHVSSTDMLSWKREPIMFAPSLEQEKDGVFSGSAVID
DNGDLRFYYTGHRWANGHDNTGGDWQVQMTALPDNDELTSATKQGMIIDCPTDKVDHHYR
DPKVWKTGDTWYMTFGVSSADKRGQMWLFSSKDMVRWEYERVLFQHPDPDVFMLECPDFF
PIKDKDGNEKWVIGFSAMGSKPSGFMNRNVSNAGYMIGTWEPGGEFKPETEFRLWDCGHN
YYAPQSFNVEGRQIVYGWMSPFVQPIPMEDDGWCGQLTLPREITLGDDGDVVTAPVAEME
GLREDTLDHGSITLDMDGEQIIADDAEAVEIEMTIDLAASTAERAGLKIHATEDGAYTYV
AYDDQIGRVVVDRQAMANGDRGYRAAPLTDAELASGKLDLRVFVDRGSVEVYVNGGHQVL
SSYSYASEGPRAIKLVAESGSLKVDSLKLHHMKSIGLE
Function This enzyme takes part in glucuronoside catabolic process. Substrates include sucrose.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Kestose
 Drug Info Preclinical Atopic dermatitis ICD11: EA80 [1]
Sucrose
 Drug Info Investigative Prematurity retinopathy ICD11: 9B71 [1]
References
1 Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298.

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