Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2151)
Drug Name
Sucrose
Synonyms
Amerfand; Amerfond; Beet sugar; Cane sugar; Confectioner's sugar; D(+)-Saccharose; D(+)-Sucrose; D-(+)-Saccharose; D-Sucrose; Granulated sugar; Microse; Rock candy; Rohrzucker; Saccharum; Sacharose; Sucraloxum [INN-Latin]; Sucrose [USAN:JAN]; Sucrose, dust; Sucrose, pure; Table sugar; White sugar; sacarosa; saccharose; sucrose; 57-50-1; CCRIS 2120; CHEBI:17992; D-Saccharose; HSDB 500; alpha-D-Glucopyranosyl beta-D-fructofuranoside; beta-D-Fructofuranosyl alpha-D-glucopyranoside; beta-D-Fructofuranosyl-alpha-D-glucopyranoside; sugar
Indication Prematurity retinopathy [ICD11: 9B71] Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 342.3 Topological Polar Surface Area 190
Heavy Atom Count 23 Rotatable Bond Count 5
Hydrogen Bond Donor Count 8 Hydrogen Bond Acceptor Count 11
Cross-matching ID
PubChem CID
5988
PubChem SID
3194 ; 3389 ; 818878 ; 820865 ; 823014 ; 823458 ; 823537 ; 825314 ; 825582 ; 825586 ; 826415 ; 826659 ; 826950 ; 826952 ; 826953 ; 827036 ; 828601 ; 828646 ; 829805 ; 831374 ; 832319 ; 832408 ; 833228 ; 833813 ; 838627 ; 839070 ; 839082 ; 839090 ; 841538 ; 854919 ; 855298 ; 855299 ; 855300 ; 3137376 ; 6436115 ; 6436116 ; 6436204 ; 7847093 ; 7887852 ; 7890628 ; 8011621 ; 8011923 ; 8020622 ; 8022577 ; 8024860 ; 8024864 ; 8027366 ; 8028161 ; 8143928 ; 8153723
ChEBI ID
CHEBI:17992
CAS Number
57-50-1
TTD Drug ID
D08TCV
Formula
C12H22O11
Canonical SMILES
C(C1C(C(C(C(O1)OC2(C(C(C(O2)CO)O)O)CO)O)O)O)O
InChI
1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1
InChIKey
CZMRCDWAGMRECN-UGDNZRGBSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Beta-fructofuranosidase (BFRU) DME1162 Bifidobacterium longum
E1CPU3_BIFLN
3.2.1.26
[2]
Fructokinase (scrK) DME1136 Fusobacterium mortiferum
SCRK_FUSMR
2.7.1.4
[3]
Glucansucrase (gtf106B) DME1495 Lactobacillus reuteri
Q5SBN3_LACRE
2.4.1.5
[4] , [5]
Sucrose phosphorylase (Spase) DME1545 Bifidobacterium longum
A0A0M4N1J6_BIFLN
2.4.1.7
[2]
Sucrose-6-phosphate hydrolase scrB (ScrB) DME1542 Anaerostipes caccae
B0MAC0_ANACD
3.2.1.26
[2]
Unclear metabolic mechanism (DME-unclear) DME1267 Anaerobutyricum hallii Not Available Not Available [6]
⏷ Show the Full List of 6  DME(s)
References
1 ClinicalTrials.gov (NCT00921544) Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening
2 Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298.
3 Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54.
4 Biosolids application affects the competitive sorption and lability of cadmium, copper, nickel, lead, and zinc in fluvial and calcareous soils. Environ Geochem Health. 2017 Dec;39(6):1365-1379.
5 Growth and tolerance of term infants fed formula with probiotic lactobacillus reuteri. Clin Pediatr (Phila). 2015 Oct;54(12):1175-84.
6 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.

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