Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1170)
DME Name Dextransucrase 4 (dsrF4), Leuconostoc mesenteroides
Synonyms Glucansucrase 4; Sucrose 6-glucosyltransferase 4; Dextransucrase IV
Gene Name dsrF4
UniProt ID
GTF4_LEUME
EC Number    EC: 2.4.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.5
Lineage    Species: Leuconostoc mesenteroides     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Leuconostocaceae
Genus: Leuconostoc
Species: Leuconostoc mesenteroides
Subspecies: Leuconostoc mesenteroides 0326
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MIRTSKKAIAVAVGLIASATASAGDATAPIFVSNAMLDKHVIYQDFAFYQPYDGTVYKTL
ARQAPELRNLGITDVWFAPPYRALNDGRFSEGYAVIDRYDLGEFPQGRGNAIATKYGTGA
QLREAIESMHRQRINAIADIVPNQMFFSQREVASVTAVDIFGNPTNPSASNVLYPGYSKG
GGLGQKQYGVIKQWQAKYENGTSPQALGIDRIMVDGAGAPYRYYGPGDARNHLPAWLEAT
DAARVGALNTIDTYLSVDGSYAAQSAATAIPVYRPYLLYYVDPRRDATVQPYLTYMRAHG
FPGNSDDAVRQSIINGNTDAVTKATNDYLALQPGYSASSEAGAAAFRFNKPSNADVNKNV
LQYEFLLGSDIDNSNATVQNETLNWQRFLLDKYGFDGFRFDAAGHYNTDILRQSAQLMSG
RYGHDMNNHLSVIESYVDPQIAFENSNGNGQLAYDGTLYSTMYNTLEQANPGGPLSDIFA
KSIVGQARFGAGRAIPNWSFVTNHDQEHNVIAKIPVPPTQKAGYTPDAAIQLAQMSIYDN
DRKQAVKQYAPYNVPSAYAVLLTNKDTVPTVFYGDLYESDKAYVSTKTPYYDAITRLLKI
RQKFVAGAQVLTYYKTNTSPSVAGQDLLASVRVGTDRGTGVATVIGNNPATDATIRVDMG
LQHANQTFTNMFGQWPERLQTDGRGVLTVHVTGSSTPQVHGYLGVWVPTSEGEGSMMGYA
S
Function This enzyme involves in the production of dextran, an extracellular glucan polymer.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
RTR-001007
 Drug Info Phase 1 Diabetes mellitus ICD11: 5A10 [1]
References
1 Transglycosylation improved caffeic acid phenethyl ester anti-inflammatory activity and water solubility by Leuconostoc mesenteroides dextransucrase. J Agric Food Chem. 2019 Apr 24;67(16):4505-4512.

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