Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1189)
DME Name Beta-hydroxysteroid dehydrogenase (hdhB), Collinsella aerofaciens
Synonyms Oxidoreductase short chain dehydrogenase/reductase family protein; COLAER_02088
Gene Name hdhB
UniProt ID
A4ECA9_9ACTN
Gene ID
42685322
EC Number    EC: 1.1.1.201     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.201
Lineage    Species: Collinsella aerofaciens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Coriobacteriales
Family: Coriobacteriaceae
Genus: Collinsella
Species: Collinsella aerofaciens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNLREKYGEWGLILGATEGVGKAFCEKIAAGGMNVVMVGRREEKLNVLAGEIRETYGVET
KVVRADFSQPGAAETVFAATEGLDMGFMSYVACLHSFGKIQDTPWEKHEAMINVNVVTFL
KCFHHYMRIFAAQDRGAVINVSSMTGISSSPWNGQYGAGKAFILKMTEAVACECEGTGVD
VEVITLGTTLTPSLLSNLPGGPQGEAVMKIALTPEECVDEAFEKLGKELSVIAGQRNKDS
VHDWKANHTEDEYIRYMGSFYRD
Structure
5FYD ; 5GT9
Function This enzyme catalyzes the oxidation of the 7beta-hydroxy group of bile acids such as ursodeoxycholate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Ursodeoxycholic acid
 Drug Info Approved Hepatic fibrosis/cirrhosis ICD11: DB93 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Dehydrocholic acid
 Drug Info Investigative Asthma ICD11: CA23 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005329 Dehydrocholic acid Dihydroxymonoketo bile acid Reduction - Reduction Dehydrocholic acid [2], [1]
MR005330 Dehydrocholic acid Monohydroxydiketoacid Reduction - Reduction Dehydrocholic acid [2], [1]
MR005331 Dehydrocholic acid Cholic acid Reduction - Reduction Dehydrocholic acid [2], [1]
References
1 Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens. Appl Microbiol Biotechnol. 2011 Apr;90(1):127-35.
2 Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man

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