Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1199)
DME Name L,D-carboxypeptidase A (ldcA), Neisseria gonorrhoeae
Synonyms Carboxypeptidase; LD-carboxypeptidase; Murein tetrapeptide carboxypeptidase; VT05_01038; ldcA
Gene Name ldcA
UniProt ID
A0A5K1KMI8_NEIGO
EC Number    EC: 3.4.17.13     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Metallocarboxypeptidase
EC: 3.4.17.13
Lineage    Species: Neisseria gonorrhoeae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Neisseriaceae
Genus: Neisseria
Species: Neisseria gonorrhoeae
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTEPTSRRRFLKTCTAAGAGLLQACGTSATSVPPLPSSHSVVKARTVPLQTPRRQSSDGN
LLRVVASSGFAEDTNRVNTALTRLYNAGFTVTNQQAGSRRFQRFAGTDAQRAADFQEVAS
GRVATPKVLMGLRGGYGAARILPHIDFASLGARMREHGTLFFGFSDVCAVQLALLAKGNM
MSFAGPMAYSDFGKPAPGAFTMDAFIKGATQNRLTVDVPYIQRTDVETEGTLWGGNLSVL
ASLAGTPYMPDIDGGILFLEDVGEQPYRIERMLNTLYLSGILGKQRAIVFGDFRMEKIRD
LYDSSYDFSAVAKHISRTAKIPVLTGFPFGHIADKITFPLGAHTRIRMNGNGGYSVAFEG
YPTLDASALTLDTLLPPPDLPIFPESGVADISE
Function This enzyme hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic side-chains.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Dithiazoline
 Drug Info Investigative Gonococcal infection ICD11: 1A70 [1]
References
1 Selective inhibition of Neisseria gonorrhoeae by a dithiazoline in mixed infections with Lactobacillus gasseri. Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00826-18.

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