Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1236)
DME Name Cytochrome P450 BM3 (cypBM3), Bacillus megaterium
Synonyms Cytochrome P450 family 102 subfamily A member 3; Cytochrome cypBM3; P450 BM3; cypBM3
Gene Name cypBM3
UniProt ID
M9TKI6_BACME
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Bacillus megaterium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus megaterium
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
DKPVQLGCKFADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFA
GDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLIQKWERLNADEHIEVP
EDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENK
RQFQDDIKVMNDLVDKIIADRKASGEQSDDLLTHYAKRKDPETGEPLDDENIRYQIITFL
IAGHETT
Function This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
Full List of Drug(s) Metabolized by This DME
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
HY-12638
 Drug Info Discontinued Tapeworm infestation ICD11: 1F7Y [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Chlorpyrifos
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Dinoterb
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 PEGylation of cytochrome P450 enhances its biocatalytic performance for pesticide transformation. Int J Biol Macromol. 2017 Dec;105(Pt 1):163-170.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.