General Information of Drug-Metabolizing Enzyme (DME ID: DME1236)
DME Name Cytochrome P450 BM3 (cypBM3), Bacillus megaterium DME Info
UniProt ID
M9TKI6_BACME
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Bacillus megaterium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus megaterium
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:    159 Xenobiotics
                              Anopheles cecropin-A amidated isoform Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02230   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Anopheles cecropin-A amidated isoform inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.5-1 microM) [1], [2]
                              Antibacterial napin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02237   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial napin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 215 microM) [3]
                              Antibacterial peptide 3910 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02238   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial peptide 3910 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [4]
                              Antibacterial peptide PMAP-23 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02242   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial peptide PMAP-23 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 microM) [5]
                              Antibacterial peptide PMAP-36 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02243   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial peptide PMAP-36 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3 microM) [6]
                              Antibacterial peptide PMAP-37 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02244   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial peptide PMAP-37 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 4 microM) [7]
                              Antibacterial protein PR-39 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02248   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial protein PR-39 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.3 microM) [8], [9]
                              Antimicrobial peptide AC-AMP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02259   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide AC-AMP1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [10], [11]
                              Antimicrobial peptide AC-AMP2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02267   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide AC-AMP2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [11]
                              Antimicrobial peptide GP-19 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02282   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide GP-19 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [12]
                              Antimicrobial peptide MJ-AMP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02262   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide MJ-AMP1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 6 ug/ml) [13], [14]
                              Antimicrobial peptide MJ-AMP2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02269   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide MJ-AMP2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 ug/ml) [13], [14]
                              Antimicrobial peptide NK-lysin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02293   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide NK-lysin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.8 microM) [15], [16]
                              Antimicrobial protein Ace-AMP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02299   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial protein Ace-AMP1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [17], [18]
                              Apidaecin-1A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02304   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Apidaecin-1A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 150 ug/ml) [19]
                              Apidaecin-1B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02305   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Apidaecin-1B inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 100 ug/ml) [19], [20]
                              Apidaecin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02306   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Apidaecin-2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 100 ug/ml) [19]
                              Arachnid gomesin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03497   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Arachnid gomesin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.2-0.4 microM) [21]
                              Armadillidin glyc-rich Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02319   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Armadillidin glyc-rich inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.5-1.25 microM) [22]
                              Arthropods theromacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05125   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Arthropods theromacin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [23]
                              Bacteriocin delta-lysin I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03137   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin delta-lysin I inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [24]
                              Bacteriocin HJ50 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02476   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin HJ50 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [25], [26]
                              Bombin H7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02468   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bombin H7 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.3 microM) [27]
                              Bombinin-like peptide BLP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02475   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bombinin-like peptide BLP-3 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.3 microM) [28]
                              Bovine cathelicidin BMAP-34 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02466   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bovine cathelicidin BMAP-34 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3 microM) [29], [30]
                              Brevinin-1E Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02521   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-1E inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.4 microM) [31], [32]
                              Brevinin-2E Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02584   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-2E inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.2 microM) [31]
                              Cathelicidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02731   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cathelicidin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 4 microM) [33], [34]
                              Cathelicidin-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02739   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cathelicidin-5 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 microM) [35], [36]
                              Cathelicidin-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02740   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cathelicidin-6 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 ug/ml) [35], [37]
                              Cecropin-A(1-7)-melittin(1-8) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02756   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(1-8) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.8 microM) [38]
                              Cecropin-A(1-7)-melittin(2-9) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02757   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(2-9) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.7 microM) [38], [39]
                              Cecropin-A(1-7)-melittin(3-10) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02758   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(3-10) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.9 microM) [38]
                              Cecropin-A(1-7)-melittin(4-11) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02759   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(4-11) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.5 microM) [38], [40]
                              Cecropin-A(1-7)-melittin(5-12) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02760   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(5-12) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.5 microM) [38]
                              Cecropin-A(1-7)-melittin(6-13) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02761   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-7)-melittin(6-13) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.5 microM) [38]
                              Cecropin-A(1-8)-Magainin-2(1-12) hybrid P18 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04430   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-8)-Magainin-2(1-12) hybrid P18 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.78 microM) [41], [42]
                              Cecropin-A(1-8)-melittin(1-10) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02762   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-8)-melittin(1-10) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.5 microM) [38]
                              Cecropin-A(1-8)-melittin(1-12) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02763   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-8)-melittin(1-12) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.2 microM) [38]
                              Cecropin-A(1-8)-melittin(1-18) hybrid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02765   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-A(1-8)-melittin(1-18) hybrid inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.4 microM) [38]
                              Cecropin-D Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02771   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-D inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 24 microM) [43]
                              Cecropin-P1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02774   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cecropin-P1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.8 microM) [44], [45]
                              Defensin MGD-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03110   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Defensin MGD-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.8 microM) [46]
                              Defensin sapecin-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04905   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Defensin sapecin-B inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [47], [48]
                              Defensin-like protein sesquin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03119   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Defensin-like protein sesquin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [49]
                              Dermaseptin-like PBN2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03162   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dermaseptin-like PBN2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.8 microM) [50]
                              Dermatoxin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03164   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dermatoxin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [51]
                              Drosophila cecropin-A1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03224   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Drosophila cecropin-A1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1-2.5 microM) [52], [53]
                              Enkelytin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03249   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enkelytin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.2-0.4 microM) [54], [55]
                              Enterocin AS-48 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03251   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin AS-48 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [56]
                              Enterocin EJ97 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03254   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin EJ97 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 4 ug/ml) [57]
                              Esculentin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03274   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Esculentin-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.1 microM) [31]
                              Esculentin-1B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03277   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Esculentin-1B inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.1 microM) [32]
                              Esculentin-2A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03299   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Esculentin-2A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.2 microM) [32]
                              Frog bombinin-like peptide BLP-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02474   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Frog bombinin-like peptide BLP-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.3 microM) [28]
                              Frog phylloxin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04575   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Frog phylloxin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.12 microM) [58]
                              Halocyntin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03522   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Halocyntin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [59]
                              Heligoland antimicrobial peptide A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04762   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Heligoland antimicrobial peptide A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.1 microM) [60]
                              Hevein-like antimicrobial peptide Ee-CBPb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03243   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hevein-like antimicrobial peptide Ee-CBPb inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [61], [62]
                              Hinnavin I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03561   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hinnavin I inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [63]
                              Human recombinant Ser-Thr-Ala-CGA1-78 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03605   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Human recombinant Ser-Thr-Ala-CGA1-78 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 30 microM) [64]
                              Hymenoptaecin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03618   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hymenoptaecin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.5-1 microM) [65]
                              Immune protein P9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02769   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Immune protein P9 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.44 microM) [66]
                              Insect attacin-C Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02333   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect attacin-C inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC > 200 microM) [67]
                              Insect cecropin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02768   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect cecropin-A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1-2.5 ug/ml) [68]
                              Insect cecropin-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02770   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect cecropin-B inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.64 microM) [43], [69]
                              Insect cecropin-D Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02772   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect cecropin-D inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [66], [70]
                              Insect defensin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03116   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect defensin A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.2-2.5 microM) [71]
                              Insect defensin B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03117   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect defensin B inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.2-2.5 microM) [71]
                              KR-12 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03712   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation KR-12 peptide inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [72]
                              Lantibiotic lichenicidin VK21 A1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03804   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lantibiotic lichenicidin VK21 A1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [73]
                              Lantibiotic lichenicidin VK21 A2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03805   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lantibiotic lichenicidin VK21 A2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [73]
                              Lunatusin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03973   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lunatusin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [74]
                              Mammal mBMAP28 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04039   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mammal mBMAP28 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 microM) [35]
                              Melittin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04057   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Melittin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.6 microM) [75]
                              Moricin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04128   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Moricin-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.09 microM) [76], [77]
                              Myeloid antimicrobial peptide BMAP-27 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04158   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Myeloid antimicrobial peptide BMAP-27 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 microM) [35]
                              Myeloid antimicrobial peptide BMAP-28 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04159   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Myeloid antimicrobial peptide BMAP-28 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 microM) [35]
                              Myticin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04166   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Myticin-A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [78]
                              Myticin-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04167   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Myticin-B inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [78]
                              Myticusin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04168   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Myticusin-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2.5-5.0 microM) [79]
                              Mytilin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04169   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mytilin-A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [80]
                              Napin-like polypeptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04235   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Napin-like polypeptide inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [81]
                              Omwaprin-a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04394   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Omwaprin-a inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [82], [83]
                              P. americana Pa-AMP-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04424   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P. americana Pa-AMP-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [84], [85]
                              P18 analog N-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04206   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analog N-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analog N-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04214   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analog N-2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.78 microM) [41]
                              P18 analog N-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04216   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analog N-3 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analog N-3L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04218   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analog N-3L inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.78 microM) [41]
                              P18 analog N-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04219   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analog N-4 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analog N-4L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04220   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analog N-4L inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.78 microM) [41]
                              P18 analog N-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04221   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analog N-5 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analog N-5L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04222   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analog N-5L inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analogue C-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02663   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analogue C-10 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02664   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-10 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [41]
                              P18 analogue C-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02672   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analogue C-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02673   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-3 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [41]
                              P18 analogue C-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02674   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-4 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [41]
                              P18 analogue C-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02676   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-5 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analogue C-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02677   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-6 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [41]
                              P18 analogue C-7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02679   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-7 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [41]
                              P18 analogue C-8 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02680   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-8 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [41]
                              P18 analogue C-9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02683   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue C-9 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [41]
                              P18 analogue L9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01823   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue L9 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.56 microM) [41]
                              P18 analogue S9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01825   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P18 analogue S9 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [41]
                              Paneth cell-specific alpha-defensin 1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04463   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Paneth cell-specific alpha-defensin 1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [86]
                              Papillosin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04468   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Papillosin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [59]
                              Penaeidin-2d Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04506   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-2d inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2.5-5 microM) [87], [88]
                              Penaeidin-3a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04507   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-3a inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2.5-5 microM) [89]
                              Penaeidin-3a T8A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01827   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-3a T8A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.12-6.25 microM) [89]
                              Penaeidin-4a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04510   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-4a inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC > 50 microM) [87], [90]
                              Penaeidin-4d Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04511   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-4d inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC > 50 microM) [87], [91]
                              Peptide leucine arginine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04545   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Peptide leucine arginine inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 20 microM) [92]
                              Peptide PMAP-36(1-20) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04661   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Peptide PMAP-36(1-20) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3 microM) [93]
                              Peptide PMAP-36(1-34) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04662   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Peptide PMAP-36(1-34) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1 microM) [93]
                              Peptide PMAP-36(1-35)2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04663   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Peptide PMAP-36(1-35)2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1 microM) [93]
                              Perinerin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04546   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Perinerin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [94]
                              Pig DBI(32-86) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03081   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pig DBI(32-86) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.69 microM) [4], [95]
                              Pilosulin P1(1-20) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04426   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pilosulin P1(1-20) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 microM) [96]
                              Plantazolicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04624   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantazolicin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [97]
                              Plasticin ANC KF Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04625   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plasticin ANC KF inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 12.5 microM) [98]
                              Plasticin PD36 K Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04626   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plasticin PD36 K inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 12.5 microM) [98]
                              Plasticin PD36 KF Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04627   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plasticin PD36 KF inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 50.25 microM) [98]
                              Ponericin G1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04695   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [99]
                              Ponericin G4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04697   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G4 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [99]
                              Pore-forming peptide ameobapore A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04707   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pore-forming peptide ameobapore A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 13 microM) [100]
                              Pyrrhocoricin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04770   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pyrrhocoricin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC > 80 microM) [101]
                              Ranacyclin-E Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04797   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ranacyclin-E inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3 microM) [102]
                              Ranacyclin-T Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04798   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ranacyclin-T inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3 microM) [102]
                              Recombinant Crassostrea Gigas Defensin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04840   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Recombinant Crassostrea Gigas Defensin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC > 20 microM) [103]
                              Sapecin-C Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04906   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sapecin-C inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [47]
                              Spheniscin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04971   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Spheniscin-2 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.4-0.8 microM) [104], [105]
                              Spider gomesin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03498   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Spider gomesin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.2-0.4 microM) [21]
                              Spinigerin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04974   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Spinigerin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.8-1.5 microM) [106], [107]
                              Stomoxyn Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04995   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Stomoxyn inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.78-1.56 microM) [107], [108]
                              Subpeptin JM4-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05004   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Subpeptin JM4-A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [109]
                              Subpeptin JM4-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05005   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Subpeptin JM4-B inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [109]
                              Temporin-1Sa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05063   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-1Sa inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 microM) [110]
                              Temporin-1Sb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05064   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-1Sb inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 46 microM) [110]
                              Temporin-1Sc Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05065   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-1Sc inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 4 ug/ml) [110]
                              Temporin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05076   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-A inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 1.2 microM) [111]
                              Temporin-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05085   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-B inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2.8 ug/ml) [111]
                              Temporin-D Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05088   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-D inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [111], [112]
                              Temporin-SHa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05105   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-SHa inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2 microM) [110]
                              Termicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05110   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Termicin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [106], [113]
                              Thanatin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05120   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2.5-5 microM) [114], [115]
                              Thanatin truncated isoform Y12M(10-21) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05304   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform Y12M(10-21) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 20-40 microM) [114]
                              Thanatin truncated isoform G18C(1-18) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03431   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform G18C(1-18) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 5-10 microM) [114]
                              Thanatin truncated isoform G19Q(1-19) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03432   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform G19Q(1-19) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 5-10 microM) [114]
                              Thanatin truncated isoform G20R(1-20) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03435   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform G20R(1-20) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2.5-5 microM) [114]
                              Thanatin truncated isoform I14M(8-21) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03622   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform I14M(8-21) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 10-20 microM) [114]
                              Thanatin truncated isoform K18M(4-21) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03681   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform K18M(4-21) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 2.5-5 microM) [114]
                              Thanatin truncated isoform V16M(6-21) Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05220   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thanatin truncated isoform V16M(6-21) inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 5-10 microM) [114]
                              Thuricin-17 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05138   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thuricin-17 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [116]
                              TL(3)[Pro3,DLeu9] Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01824   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation TL(3)[Pro3,DLeu9] inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 3.125 microM) [117]
                              Type 1 invertebrate defensin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03100   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Type 1 invertebrate defensin inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium [118]
                              Vasostatin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05229   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Vasostatin-1 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.2 microM) [64]
                              Venom antimicrobial peptide-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05230   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Venom antimicrobial peptide-6 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.25 microM) [119]
                              Venom antimicrobial peptide-9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05231   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Venom antimicrobial peptide-9 inhibits the drug-metabolizing activity of Cytochrome P450 BM3 (cypBM3) from Bacillus megaterium (MIC = 0.25 microM) [119]
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