Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1245)
DME Name Nitroreductase (NTR), Clostridium perfringens
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; AC1_0194
Gene Name NTR
UniProt ID
B1R7B9_CLOPF
Gene ID
29572702
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Clostridium perfringens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium perfringens
Subspecies: Clostridium perfringens B str. ATCC 3626
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKLDRKDIIDIFNFRFATKEFTGEIIPKEDMEMIAETARLSPSSFGLEPWKFLIVENKEL
IKEISEVSWGFQRQASTTSHIVIALTKAGSEVKYDSDYIRNLWINTKGVSEEFFEGIKDV
LKNFQVGKLEADETNEKLLEWSKRQTYIALGNMMTAAAMREIDSCAIEGFDKEKVEEILA
KKGILDKEKYELTYLIAFGYRKEDPNRKKSRLPKSEVIQWVE
Function This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Metronidazole
 Drug Info Approved Amebiasis ICD11: 1A36 [1]
Nitrofurantoin
 Drug Info Approved Infectious cystitis ICD11: GC00 [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
P-nitrobenzoic acid
 Drug Info Investigative Discovery agent ICD: N.A. [2]
References
1 Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol. 1979 Dec 15;28(24):3611-5.
2 Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.

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