Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1247)
DME Name Nitroreductase (NTR), Enterobacter cloacae
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; nfsB; nfsI
Gene Name nfsB
UniProt ID
NFSB_ENTCL
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Enterobacter cloacae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Enterobacter
Species: Enterobacter cloacae
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MDIISVALKRHSTKAFDASKKLTAEEAEKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV
AKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEEADGRFNTPEAKAANHKG
RTYFADMHRVDLKDDDQWMAKQVYLNVGNFLLGVGAMGLDAVPIEGFDAAILDEEFGLKE
KGFTSLVVVPVGHHSVEDFNATLPKSRLPLSTIVTEC
Structure
1KQB ; 1KQC ; 1KQD ; 1NEC ; 5J8D ; 5J8G
Function This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          3 Drugs
Metronidazole
 Drug Info Approved Amebiasis ICD11: 1A36 [1]
Secnidazole
 Drug Info Approved Amebiasis ICD11: 1A36 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
AI3-23606
 Drug Info Phase 1 Trypanosomiasis ICD11: 1F51 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Quinone
 Drug Info Investigative Prostate cancer ICD11: 2C82 [1]
References
1 Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60.

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