| General Information of DME (ID: DME1292) |
| DME Name |
VanB ligase (vanB), Enterococcus faecalis
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| Synonyms |
Vancomycin B-type resistance protein VanB; D-alanylalanine synthetase VanB; D-alanine--D-alanine ligase VanB; D-Ala-D-Ala ligase VanB; vanB; vanB2; EF_2294
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| Gene Name |
vanB
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 6.3.2.4 (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
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| Lineage |
Species: Enterococcus faecalis (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecalis
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MNKIKVAIIFGGCSEEHDVSVKSAIEIAANINTEKFDPHYIGITKNGVWKLCKKPCTEWE
ADSLPAIFSPDRKTHGLLVMKEREYETRRIDVAFPVLHGKCGEDGAIQGLFELSGIPYVG
CDIQSSAACMDKSLAYILTKNAGIAVPEFQMIEKGDKPEARTLTYPVFVKPARSGSSFGV
TKVNSTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF
RIHQENEPEKGSENAMIIVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI
VLNEVNTLPGFTSYSRYPRMAAAAGITLPALIDSLITLAIER
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| Pathway |
Two-component system (efa02020 ) |
| Vancomycin resistance (efa01502 ) |
| Function |
This enzyme is required for high-level resistance to glycopeptides antibiotics. D-Ala--D-Ala ligase of altered specificity catalyzes ester bond formation between D-Ala and various D-hydroxy acids and produce a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin binding.
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