Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1292)
DME Name	VanB ligase (vanB), Enterococcus faecalis	DME Info
UniProt ID	VANB_ENTFA
EC Number	EC: 6.3.2.4 (Click to Show/Hide the Complete EC Tree) Ligase Carbon-nitrogen ligase Peptide synthase EC: 6.3.2.4
Lineage	Species: Enterococcus faecalis (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Enterococcaceae Genus: Enterococcus Species: Enterococcus faecalis
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Amino Acid(s), Peptide(s) or Protein(s)
Peptide		Click to Show/Hide the Full List of Xenobiotics: 180 Xenobiotics
A. clavatus peptide AcAMP		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02122 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	A. clavatus peptide AcAMP inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 50 ug/ml)				[1]
Antibacterial protein LL-37		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02247 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antibacterial protein LL-37 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[2]
Arachnid gomesin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03497 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Arachnid gomesin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 6.2-12.5 microM)				[3]
Armadillidin glyc-rich		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02319 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Armadillidin glyc-rich inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[4]
Ascaphin-5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02325 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ascaphin-5 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 100 microM)				[5]
Bac2A variant Bac8a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02357 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant Bac8a inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 16 ug/ml)				[6]
Bac2A variant Bac8b		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02358 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant Bac8b inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 8 ug/ml)				[6]
Bac2A variant Bac8c		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02360 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant Bac8c inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2 ug/ml)				[6]
Bac2A variant Bac8d		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02361 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant Bac8d inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 32 ug/ml)				[6]
Bac2A variant G1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03428 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant G1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 31 ug/ml)				[6]
Bac2A variant G12		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03430 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant G12 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 31 ug/ml)				[6]
Bac2A variant G2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03434 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant G2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 31 ug/ml)				[6]
Bac2A variant K7		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03684 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant K7 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 125 ug/ml)				[6]
Bac2A variant R11		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04783 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant R11 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 8 ug/ml)				[6]
Bac2A variant R2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04784 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant R2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 16 ug/ml)				[6]
Bac2A variant R3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04785 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant R3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 8 ug/ml)				[6]
Bac2A variant R5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04786 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant R5 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 125 ug/ml)				[6]
Bac2A variant Sub2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05000 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant Sub2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 4 ug/ml)				[6]
Bac2A variant Sub3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05001 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant Sub3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 4 ug/ml)				[6]
Bac2A variant Sub5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05002 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant Sub5 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2 ug/ml)				[6]
Bac2A variant Sub6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05003 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant Sub6 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 8 ug/ml)				[6]
Bac2A variant W10		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05264 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant W10 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 4 ug/ml)				[6]
Bac2A variant W3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05267 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bac2A variant W3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2 ug/ml)				[6]
Bactenecin bac2I-NH2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02356 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin bac2I-NH2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 32 ug/ml)				[7]
Bactenecin bacP2R-NH2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02366 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin bacP2R-NH2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 32 ug/ml)				[7]
Bactenecin bacP3R-V		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02368 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin bacP3R-V inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 64 ug/ml)				[7]
Bactenecin cyclic derivative BacP1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02365 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin cyclic derivative BacP1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 64 ug/ml)				[7]
Bactenecin cyclic derivative BacP3R		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02367 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin cyclic derivative BacP3R inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 32 ug/ml)				[7]
Bactenecin cyclic derivative BacR		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02369 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin cyclic derivative BacR inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 32 ug/ml)				[7]
Bactenecin cyclic derivative BacW		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02388 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin cyclic derivative BacW inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 8 ug/ml)				[7]
Bactenecin cyclic derivative BacW2R		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02389 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin cyclic derivative BacW2R inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2 ug/ml)				[7]
Bacteriocin delta-lysin I		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03137 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin delta-lysin I inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[8]
Bacteriocin hiracin-JM79		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02377 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin hiracin-JM79 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[9]
Bacteriocin lacticin Q		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03771 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin lacticin Q inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[10]
Bacteriocin leucocin N		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03854 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin leucocin N inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 5.20 microM)				[11]
Bacteriocin leucocin Q		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03855 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin leucocin Q inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 4.10 microM)				[11]
Bacteriocin plantarican ASM1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02382 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin plantarican ASM1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[12]
Bactridin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02386 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactridin-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 34 microM)				[13], [14]
Bactridin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02387 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactridin-2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 65 microM)				[13], [14]
BMAP-28		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02465 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	BMAP-28 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[15]
Bovine dodecapeptide linear variant Bac2A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02355 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine dodecapeptide linear variant Bac2A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 17 ug/ml)				[6], [16]
Bovine lactoferricin bLf 20-29		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02463 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine lactoferricin bLf 20-29 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 15 microM)				[17]
Bovine lactoferrin LFB-6RW		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03873 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine lactoferrin LFB-6RW inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 30 microM)				[17]
Bovine lactoferrin LFB-KW		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03874 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine lactoferrin LFB-KW inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 22.5 microM)				[17]
Bovine lactoferrin LFB-RF		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03875 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine lactoferrin LFB-RF inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 22.5 microM)				[17]
Bovine lactoferrin LFB-RI		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03876 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine lactoferrin LFB-RI inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 15 microM)				[17]
Bovine lactoferrin LFB-RW		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03877 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine lactoferrin LFB-RW inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 11.25 microM)				[17]
Bovine lactoferrin LFB-Rwa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03878 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bovine lactoferrin LFB-Rwa inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 22.5 microM)				[17]
Bradykinin-potentiating BmK3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02491 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bradykinin-potentiating BmK3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 57.1 microM)				[18], [19]
Brevinin-1AUa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02496 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1AUa inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 13 microM)				[20]
Brevinin-1AUb		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02497 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1AUb inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 6 microM)				[20]
Brevinin-1CG2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02509 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1CG2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 19 microM)				[21]
Brevinin-1CG3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02510 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1CG3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 75 microM)				[21]
Brevinin-1CG4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02511 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1CG4 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 9 microM)				[21]
Brevinin-1CG5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02512 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1CG5 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 9 microM)				[21]
Brevinin-1HN1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02524 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1HN1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 19 microM)				[22]
Brevinin-1TSa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02566 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1TSa inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 50 microM)				[23]
Brevinin-2TSa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02637 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-2TSa inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 25 microM)				[23]
Caprine lalctoferricin fragment cLf 20-29		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02872 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Caprine lalctoferricin fragment cLf 20-29 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 300 microM)				[17]
Carnobacteriocin CbnB2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02718 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Carnobacteriocin CbnB2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[24]
Carnocyclin CclA		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02721 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Carnocyclin CclA inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[25], [26]
Cathelicidin cjaRL-37		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02864 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin cjaRL-37 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 32 microM)				[2]
Cathelicidin CP-11		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02931 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin CP-11 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 64 ug/ml)				[27], [28]
Cathelicidin HmdSL-37		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03579 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin HmdSL-37 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[2]
Cathelicidin PobRL-37		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04680 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin PobRL-37 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1-2 microM)				[2]
ccTP derivative Arg13		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01812 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	ccTP derivative Arg13 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1.9 microM)				[29]
ccTP derivative Arg4,8		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01815 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	ccTP derivative Arg4,8 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1.0 microM)				[29]
ccTP derivative Arg4,8,13		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01814 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	ccTP derivative Arg4,8,13 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 0.7 microM)				[29]
ccTP derivative Arg4,8,13 Lys18		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01813 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	ccTP derivative Arg4,8,13 Lys18 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1.4 microM)				[29]
Cliotide cT1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02875 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cliotide cT1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[30]
Cliotide cT2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02876 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cliotide cT2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[30]
Cliotide cT3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02877 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cliotide cT3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[30]
Cliotide cT4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02878 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cliotide cT4 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[30]
CP11CN peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02932 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	CP11CN peptide inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 64 ug/ml)				[31]
Cryptdin related peptide CRS4C-1a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02958 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cryptdin related peptide CRS4C-1a inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[32]
Cryptdin related peptide CRS4C-1d		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02959 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cryptdin related peptide CRS4C-1d inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[32]
Cryptdin related peptide CRS4C-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02960 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cryptdin related peptide CRS4C-2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[32]
Cryptdin related peptide CRS4C-2b		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02961 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cryptdin related peptide CRS4C-2b inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[32]
Cryptdin related sequence CRS4C-3c		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02955 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cryptdin related sequence CRS4C-3c inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[32]
Cupiennin-1D		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03021 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cupiennin-1D inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1.25-2.50 microM)				[33], [34]
Curvacin A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03025 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Curvacin A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[35], [36]
D-amino-acid pexiganan MSI-214		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03073 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	D-amino-acid pexiganan MSI-214 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 16 ug/ml)				[37]
Dermadistinctin DD L		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03146 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dermadistinctin DD L inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 10 microM)				[38]
Dermadistinctin DD M		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03147 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dermadistinctin DD M inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 38 microM)				[39]
Dermadistinctin DD Q1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03148 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dermadistinctin DD Q1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 22 microM)				[39]
Dermadistinctin DD Q2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03149 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dermadistinctin DD Q2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 11 microM)				[39]
Dermcidin chain DCD-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03082 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dermcidin chain DCD-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[40]
Distinctin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03197 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Distinctin-2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 14.5 microM)				[41]
Enterocin 96		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03250 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin 96 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[42]
Enterocin B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03252 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin B inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 0.0869 microM)				[43], [44]
Enterocin EJ97		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03254 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin EJ97 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 6 ug/ml)				[45]
Enterocin RJ-11		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03258 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin RJ-11 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[46]
Enterocin X alpha		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03259 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin X alpha inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 0.0508 microM)				[47]
Enterocin X beta		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03260 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin X beta inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 0.813 microM)				[47]
Fallaxidin 3.1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03381 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Fallaxidin 3.1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 100 microM)				[48]
Fallaxidin 3.2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03382 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Fallaxidin 3.2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 100 microM)				[48]
Hagfish HFIAP-1/2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03556 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hagfish HFIAP-1/2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 32 ug/ml)				[49]
Hagfish HFIAP-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03557 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hagfish HFIAP-3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 32 ug/ml)				[49]
Halocyntin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03522 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Halocyntin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[50]
Hematopoietic antimicrobial MgCath37		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03540 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hematopoietic antimicrobial MgCath37 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 32 ug/ml)				[49]
Human beta-defensin hBD-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03588 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Human beta-defensin hBD-2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 15 ug/ml)				[51]
Human lalctoferricin hLf(21-30)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03569 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Human lalctoferricin hLf(21-30) inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 300 microM)				[17]
Hydramacin Hm-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03609 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hydramacin Hm-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[52], [53]
Hylin-a1 Hy-a1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03616 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hylin-a1 Hy-a1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 16 microM)				[54]
Indolicidin derivative chain a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02820 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Indolicidin derivative chain a inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 64 ug/ml)				[27]
Indolicidin derivative CP10A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02930 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Indolicidin derivative CP10A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 8 ug/ml)				[31]
Jindongenin-1a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03675 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Jindongenin-1a inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 60 microM)				[55]
Kassinatuerin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03697 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Kassinatuerin-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 12.5 microM)				[56], [57]
L-amino-acid oxidase		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03793 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L-amino-acid oxidase inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 32 microM)				[58]
Lactacin-F subunit LafA		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03768 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Lactacin-F subunit LafA inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[59], [60]
Lactacin-F subunit LafX		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03769 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Lactacin-F subunit LafX inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[61], [59]
Linear bactenecin bac2S-NH2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03904 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Linear bactenecin bac2S-NH2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 4 ug/ml)				[7]
Linear bactenecin bacS-NH2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03905 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Linear bactenecin bacS-NH2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 16 ug/ml)				[7]
M-ctenitoxin-Cs1a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04051 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	M-ctenitoxin-Cs1a inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2.50-5.00 microM)				[33], [62]
M-ctenitoxin-Cs1c		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04052 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	M-ctenitoxin-Cs1c inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[33]
M-ctenitoxin-Cs1d		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04053 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	M-ctenitoxin-Cs1d inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1.25-2.50 microM)				[33], [34]
Magainin-I peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03986 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Magainin-I peptide inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[63]
Mastoparan MP-L		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04001 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mastoparan MP-L inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 25 microM)				[64]
Mundticin ATO6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04150 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mundticin ATO6 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[65]
Mundticin KS		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04151 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mundticin KS inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[66]
Murine lalctoferricin fragment mLf(20-29)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04118 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Murine lalctoferricin fragment mLf(20-29) inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 300 microM)				[17]
Mytilin-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04169 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mytilin-A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[67]
Neurokinin A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04249 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Neurokinin A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 500 ug/ml)				[68]
Neutrophil defensin HANP-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04259 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Neutrophil defensin HANP-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[69]
Neutrophil defensin HANP-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04261 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Neutrophil defensin HANP-2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[69]
Neutrophil defensin HANP-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04265 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Neutrophil defensin HANP-3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[69]
Neutrophil defensin HANP-4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04268 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Neutrophil defensin HANP-4 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[69]
Opistoporin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04399 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Opistoporin-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 12.5 microM)				[70]
Palustrin-2AJ1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04444 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Palustrin-2AJ1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 20 microM)				[55]
Pandinin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04461 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pandinin-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1.3 microM)				[71], [72]
Pandinin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04462 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pandinin-2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2.4 microM)				[73]
Paneth cell-specific alpha-defensin 1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04463 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Paneth cell-specific alpha-defensin 1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[74]
Papillosin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04468 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Papillosin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[50]
Penocin A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04521 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penocin A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[75], [76]
Phylloseptin PS-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04569 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Phylloseptin PS-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 4.0 microM)				[77], [78]
Piscidin Pis-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04612 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Piscidin Pis-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 5-10 microM)				[79]
Piscidin Pis-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04613 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Piscidin Pis-2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 5-10 microM)				[80]
Plantaricin W alpha		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04622 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Plantaricin W alpha inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[81]
Plantaricin W beta		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04623 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Plantaricin W beta inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[81]
PM1 linear derivative PM1-S		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04660 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	PM1 linear derivative PM1-S inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2 ug/ml)				[82]
Polyphemusin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04690 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Polyphemusin-1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1 ug/ml)				[83], [82]
Ponericin G1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04695 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin G1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[84]
Ponericin G3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04696 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin G3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[84]
Ponericin-L2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04699 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-L2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[84]
Ponericin-W1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04700 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[84]
Ponericin-W3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04701 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[84]
Ponericin-W4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04702 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W4 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[84]
Ponericin-W5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04703 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W5 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[84]
Ponericin-W6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04704 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W6 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[84]
Porcine lactoferricin fragment pLf(20-29)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04657 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Porcine lactoferricin fragment pLf(20-29) inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 300 microM)				[17]
Ranatuerin-2AUa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04809 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ranatuerin-2AUa inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 40 microM)				[20]
RTD peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04863 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	RTD peptide inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1.2 microM)				[29]
Sakacin 5X		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04896 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Sakacin 5X inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[85]
Sakacin P		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04898 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Sakacin P inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[86], [87]
Siamycin I		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04936 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Siamycin I inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[88]
Signiferin-2.1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04937 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Signiferin-2.1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 100 microM)				[89]
Skin peptide tyrosine-tyrosine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04950 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Skin peptide tyrosine-tyrosine inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 10 ug/ml)				[90], [91]
Spider gomesin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03498 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Spider gomesin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 6.2-12.5 microM)				[3]
Stomoxyn		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04995 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Stomoxyn inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 0.78-1.56 microM)				[92], [93]
Styelin A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04998 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Styelin A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2 ug/ml)				[94]
Styelin B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04999 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Styelin B inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2 ug/ml)				[94]
Subpeptin JM4-B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05005 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Subpeptin JM4-B inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[95]
Substance P		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05006 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Substance P inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[96]
substance P antagonist		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05007 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	substance P antagonist inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[96]
Temporin-1Sa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05063 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Sa inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 10 microM)				[97]
Temporin-1Sb		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05064 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Sb inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 116 microM)				[97]
Temporin-1Sc		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05065 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Sc inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC > 80 ug/ml)				[97]
Temporin-1Va		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05073 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Va inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 40 microM)				[98]
Temporin-1Vb		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05074 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Vb inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 20 microM)				[98]
Temporin-1Vc		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05075 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Vc inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 40 microM)				[98]
Temporin-PE		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05097 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-PE inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 8.0 microM)				[99]
Temporin-PEa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05098 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-PEa inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2.0 microM)				[99]
Temporin-PEb		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05099 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-PEb inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 2.0 microM)				[99]
Tricystine cyclic cystine TP		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05170 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Tricystine cyclic cystine TP inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 1.0 microM)				[29]
Ubericin-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05196 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ubericin-A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[100]
V681 peptide derivative S11AD		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04886 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	V681 peptide derivative S11AD inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 12.7 ug/ml)				[101]
V681 peptide derivative S11G		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04880 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	V681 peptide derivative S11G inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 12.7 ug/ml)				[101]
V681 peptide derivative V13G		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05212 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	V681 peptide derivative V13G inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis (MIC = 50.8 ug/ml)				[101]
Variacin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05228 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Variacin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[102]
Weissellin-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05283 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Weissellin-A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[103]
Pharmaceutical Agent(s)
Approved/Marketed Drug		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Vancomycin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05224 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Vancomycin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[15]
Drug in Phase 2 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Salicylic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00546 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2/3
DME Modulation	Salicylic acid inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[104]
Investigative Agent		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Ethyl gallate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03357 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Ethyl gallate inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[105]
Methyl gallate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04106 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Methyl gallate inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[105]
Other Chemical Compound(s) or Element(s)
Food Additive		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Propyl gallate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04727 XEOTIC Info		Gene Form	Protein
Classification	Food Additive
DME Modulation	Propyl gallate inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[105]
Chemical Compound		Click to Show/Hide the Full List of Xenobiotics: 4 Xenobiotics
3-(3-fluorophenyl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01961 XEOTIC Info		Gene Form	Protein
Classification	Chemical Compound
DME Modulation	3-(3-fluorophenyl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[106]
3-(pyridin-3-yl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01966 XEOTIC Info		Gene Form	Protein
Classification	Chemical Compound
DME Modulation	3-(pyridin-3-yl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[106]
Butyl gallate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02660 XEOTIC Info		Gene Form	Protein
Classification	Chemical Compound
DME Modulation	Butyl gallate inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[105]
Hexyl gallate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03555 XEOTIC Info		Gene Form	Protein
Classification	Chemical Compound
DME Modulation	Hexyl gallate inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecalis				[105]

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