Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1331)
DME Name Nitroreductase (NTR), Clostridium sporogenes
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; NCTC13020_02816; nfrA2_4
Gene Name nfrA2_4
UniProt ID
A0A2X3BKF5_CLOSG
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Clostridium sporogenes     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium sporogenes
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNAILKRRSIRKYKDKKISDDIVEELLRAGMAAPSAVNEQPWQFIVLRDKETMKKITKVH
EYSKMLLEADVAIVVCGDKSKELVDDFWVQDCSAATENILIEAQDKGLGAVWLGVYPIKE
RVDGIKEILNLPEGITPLSVIPIGYPDEKKEPADRSNKERVHYDKW
Function This enzyme contains FMN and can utilize NADH and NADPH with similar reaction rates. It also reduces riboflavin and FAD, but more slowly.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrofurantoin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1], [2]
References
1 Biotransformation of 1-nitropyrene in intestinal anaerobic bacteria. Microbiol Immunol. 1982;26(11):993-1005.
2 Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.

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