Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1453)
DME Name Unclear metabolic mechanism (DME-unclear), Providencia rettgeri
Gene Name DME-unclear
Lineage    Species: Providencia rettgeri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Providencia
Species: Providencia rettgeri
Subspecies: Providencia rettgeri DSM 1131
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          8 Drugs
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Clemastine fumarate
 Drug Info Approved Pulmonary oedema ICD11: CB01 [1]
Loperamide hydrochloride
 Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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