Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1662)
DME Name Cytochrome P450 121A1 (cyp121), Mycobacterium tuberculosis
Synonyms Cytochrome P450 family 121 subfamily A member 1; Cytochrome P450 121; Cytochrome P450 MT2; MTCY339.34c; Mycocyclosin synthase; Rv2276; cyp121
Gene Name cyp121
UniProt ID
CP121_MYCTU
Gene ID
888373
EC Number    EC: 1.14.19.70     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Oxygen paired donor oxidoreductase
EC: 1.14.19.70
Lineage    Species: Mycobacterium tuberculosis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF
SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL
LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI
NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS
FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR
KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE
ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW
Structure
1N40 ; 1N4G ; 2IJ5 ; 2IJ7 ; 3CXV ; 3CXX ; 3CXY ; 3CXZ ; 3CY0 ; 3CY1 ; 3G5F ; 3G5H ; 4G1X ; 4G2G ; 4G44 ; 4G48 ; 4ICT ; 4IPS ; 4IPW ; 4IQ7 ; 4IQ9 ; 5IBD ; 5IBE ; 5IBF ; 5IBG ; 5IBH ; 5IBI ; 5IBJ ; 5OP9
Function This enzyme is a P-450 heme-thiolate protein, and it catalyzes C-C bond formation between the carbons ortho to the phenolic hydroxyl of cyclo(L-tyr-L-tyr) (cYY) producing mycocyclosin. The enzme also can use cyclo(L-Tyr-L-Phe) (cYF), cyclo(L-Tyr-L-Trp) (cYW) and cyclo(L-Tyr-L-3,4-dihydroxyphenylalanine) (cY-DOPA) as substrate.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Phytanic acid
 Drug Info Investigative Adrenomyeloneuropathy ICD11: 5C57 [1]
References
1 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.

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