Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1687)
DME Name D-Lactate dehydrogenase (ldhA), Lactobacillus delbrueckii
Synonyms Glycolate dehydrogenase; D-lactate ferricytochrome C oxidoreductase; Fermentative lactate dehydrogenase; D-LDH; Ldb0101; ldhA
Gene Name ldhA
UniProt ID
LDHD_LACDA
Gene ID
4085369
EC Number    EC: 1.1.1.28     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.28
Lineage    Species: Lactobacillus delbrueckii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus delbrueckii
Subspecies: Lactobacillus delbrueckii subsp. bulgaricus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTKIFAYAIREDEKPFLKEWEDAHKDVEVEYTDKLLTPETVALAKGADGVVVYQQLDYTA
ETLQALADNGITKMSLRNVGVDNIDMAKAKELGFQITNVPVYSPNAIAEHAAIQAARILR
QDKAMDEKVARHDLRWAPTIGREVRDQVVGVIGTGHIGQVFMQIMEGFGAKVIAYDIFRN
PELEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLV
DTDAVIRGLDSGKIFGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVTPHTAF
YTTHAVRNMVVKAFDNNLELVEGKEAETPVKVG
Structure
1DLD ; 1J49 ; 1J4A
Pathway Metabolic pathways (ldb01100 )
Microbial metabolism in diverse environments (ldb01120 )
Pyruvate metabolism (ldb00620 )
Function This enzyme has D-lactate dehydrogenase activity.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
DB-053072
 Drug Info Phase 1 Prostate cancer ICD11: 2C82 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004262 D-lactaldehyde Pyruvate Unclear - Unclear Methylglyoxal [2]
MR004256 D-lactate Pyruvate Unclear - Unclear Methylglyoxal [2]
References
1 Cloning of D-lactate dehydrogenase genes of Lactobacillus delbrueckii subsp. bulgaricus and their roles in D-lactic acid production. 3 Biotech. 2017 Jul;7(3):194.
2 Cells producing their own nemesis: understanding methylglyoxal metabolism

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