Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1779)
DME Name Dipeptidylpeptidase IV (DPP4), Streptococcus suis
Synonyms Bacterial dipeptidyl peptidase 4; Adenosine deaminase binding protein; Adenosine deaminase complexing protein; Adenosine deaminase-binding protein; Amino acyl-prolyl dipeptidyl aminopeptidase; Bacterial DPP4; E8L09_04090
Gene Name DPP4
UniProt ID
A0A4T2GYT7_STRSU
EC Number    EC: 3.4.14.5     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Di/tripeptidyl peptidase
EC: 3.4.14.5
Lineage    Species: Streptococcus suis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus suis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human blood.
Sequence
MKKTFVRIATFLMLVCLFPVQLVQACSGFIIGKGLTTDGSILYGRTEDYPYPPNNGAHNK
NYIVVPAATYAKGDMLVDESFGFTAPHLANEFKYTSTPDAARGDGSNGNFGAHGFNEKGV
SMTATVTAIPNKKILAVDPLVTAGGLGEAILIDYVLPRVTSAREGIELIAKTIDEKGSAE
GNIIVIADKNEVWYMEILSGHQYVAIKFPEDKYAIFANTYYLGHVDFTDTENVIASAKVE
EVAKQAENYMMVDGKFHIAKSYGPENYADGDRSRTYAGIKLLDPASSVTYEDAVYDLLRQ
PTDPSRRFSLQDTFALQRNRFEHLPEFRPDDEAGKVKQGDNGANDQAADATYKYALGNEN
VIDAHVYQINSSLPSAFGGTVWLGLAQTRNTPYVPFYGIVTDTYEAFKNRSASYDANSWY
WTVQNIDKMAISHPELFGTSIQEKWIALEKEWIAAQAALDAQYAGLSEDAAVALAPTVTE
ATLARSAEIFAQLKAVEAEMMAKIEVVTTPSSSGTETSTSTSQSTSTSDTGGATDTSSSS
GTVVSSDKKVTPTNKKGKSNLPSTGEQVSILLVALGVAGILTAIFLHRKKSNKE
Function This enzyme cleaves X-proline or X-alanine dipeptides from the N-terminus of polypeptides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
PR-39
 Drug Info Investigative Ulcerative colitis ICD11: DD71 [1], [2]
References
1 Dipeptidylpeptidase IV of Streptococcus suis degrades the porcine antimicrobial peptide PR-39 and neutralizes its biological properties. Microb Pathog. 2018 Sep;122:200-206.
2 Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases? Virulence. 2014 May 15;5(4):477-97.

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