Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1864)
DME Name Flavin adenine dinucleotide dehydrogenase (fadd), Clostridium leptum
Synonyms FAD pyrophosphorylase; FAD synthase; FMN adenylyltransferase
Gene Name apbE1
UniProt ID
APBE1_KLEP3
EC Number    EC: 1.5.1.37     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.37
Lineage    Species: Clostridium leptum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Clostridium
Species: Clostridium leptum
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MDMTFFRAALLGACVLLSGCDSATTPASPASTATVLDGKTMGTFWRVSVIGVDEAKAEAL
RAKVQAQLDADDRLLSTWKNDSALMRFNHAADTRPWPVSEAMVDIVTLSLRIGAKTHGAM
DITVGPLVNLWGFGPDKQPVTTPDAQAIAAAKARTGLQHLQVINQSGRQFLQKDIPDLFV
DLSTVGEGYAADHLARLMEQEGISRYLVSVGGALVSRGMNGEGKPWRVAIQKPTDRENAV
QAIVDINGHGISTSGSYRNYYELDGKRISHVIDPQTGQPITHKLVSVTVIAPTALEADGW
DTGLMVLGPEKAQQVVREQGLAVYMIVKEGEGFKTWMSPQFRTFLVGEKN
Function This enzyme can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. But it can not reduce riboflavin and does not use NADPH as acceptor.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
RO-7-0207
 Drug Info Phase 3 Colon cancer ICD11: 2B90 [1]
References
1 Reduction of azo dyes and nitroaromatic compounds by bacterial enzymes from the human intestinal tract. Environ Health Perspect. 1995 Jun;103 Suppl 5:17-9.

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