Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1905)
DME Name Cytochrome P450 147G1 (cyp147), Mycobacterium marinum
Synonyms Cytochrome P450 family 147 subfamily G member 1; P450 147G1; MMAR_2930; P450 147G1; cyp147G1
Gene Name cyp147G1
UniProt ID
B2HE89_MYCMM
EC Number    EC: 1.14.15.28     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.28
Lineage    Species: Mycobacterium marinum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium marinum
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MNAETAWAEAMKFENRPNPYPYFDELRKTPVAKVAEKTYVVTGYRELLALAHDPRISSDI
TRSPSGFGGEAPQPEPGSEHVQAYGQDASIIVSDPPDHDRARRQVMRHFAPPHSPDLIPS
MEPFVVRLANDLLNQASARGSTRLDVVEDFAYPIPVAVICKILGVPIEDEPKFHAWIFDF
MAGTDLGPEGDTEEGQVLAEKGRVSTAALTDYLGDLVRSYAKTPGEGLLSKLLHDDGPDG
PMSVPETTANALLLLVAGHDSTVNTITNCVMTLLRNPGSWDLVRQRPELIPRTIEEVQRL
QSAVQFFPSRSATDEIEIGGTVIPAGSAVHLIYAAANRDPRRFDNPNRFDPLREDNEHFG
WGSGIHTCMGGPLARLEVNLAVEIFLRRVQSPKLVVDPPPYRHNQIFRGPRHLWVDFAAI
TE
Function This enzyme catalyzes the selective hydroxylation of linear and -2 methyl branched fatty acids at the -1 position. Substrates of Cytochrome P450 147G1 include fatty acids ranging from octanoic to hexadecanoic acid.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Omega-3 Fatty acids
 Drug Info Phase 4 Periodontal disease ICD11: DA0C [1]
References
1 Selective Omega-1 oxidation of fatty acids by CYP147G1 from Mycobacterium marinum. Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):408-417.

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