Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1911)
DME Name Sulfatase (sulF), Parabacteroides johnsonii
Synonyms Dehydroepiandrosterone sulfatase; Sulfate sulfatase; Cholesterol sulfate sulfohydrolase; Arylsufatase; Arylsulfatase C; AtsA; ASC; DDZ04_02500
Gene Name DDZ04_02500
UniProt ID
A0A354WVI8_9BACT
EC Number    EC: 3.1.6.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Sulfuric ester hydrolase
EC: 3.1.6.1
Lineage    Species: Parabacteroides johnsonii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Parabacteroides
Species: Parabacteroides johnsonii
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKKVLFLILNYFAWLPLFVIQKPWFMTYNHPSAGNISLKDGWEVILHGLKLDCTVAGYL
TVIPLLMTLISIWVTGKWYKKGIYAYTVMALLAITAIFSVDVALYAFWGFRIDSTLLFYL
QSPKDALASIPARLFLQQTTSFLIYSTLGYLYLKRIIINHVPVEPVSNKVGATFAIIIVG
AILFIPIRGGVTTSTANVGMVYFSQNQFLNHAAINPCFSLLSSLSKQEDFSKQFNFFDEK
ERQDNIESLLSPVTSSDTTRILLKTRTPDILIIILESFSANVVEITGGLPDITPHLNQLG
KEGVLFSHVYANSFRTDRGLVAILNGYPAQPTTSIMKYPAKSQTLPSIASSLRKAGYRSD
MLYGGDINFTNMQSYFFSSGYSQITSDVDFPISDRLSKWGANDDVTFRFLLDHLKGREKE
KAPWMTTFLTLSSHEPFEVPYHRFSHPYLNSVAFTDSCLGNFISRLKQSEIWDNLLIVLV
ADHGFRYPEQLKDYEPDRFHIPMIWSGGAINKPAEINTICNQTDLAATLLGQLGISHQEY
SFSKNILSPHRCDYSFYTFNNGFAFADSLGRYTIYDNESNRVLMEDAGNTMDRLQKGKAL
LQTLYDDLGNR
Function This enzyme catalyzes the hydrolysis of sulfate esters.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Estrone sulfate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Parabacteroides pacaensis sp. nov. and Parabacteroides provencensis sp. nov., two new species identified from human gut microbiota. New Microbes New Infect. 2020 Jan 7;34:100642.

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