Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1911)
DME Name Sulfatase (sulF), Parabacteroides johnsonii DME Info
UniProt ID
A0A354WVI8_9BACT
EC Number    EC: 3.1.6.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Sulfuric ester hydrolase
EC: 3.1.6.1
Lineage    Species: Parabacteroides johnsonii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Parabacteroides
Species: Parabacteroides johnsonii
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Estrone sulfate Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-sulF interaction [1], [2]
Description The interaction, between human Cytochrome P450 1A2 and Sulfatase from Parabacteroides johnsonii which collectively metabolize the drug Estrone sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-sulF interaction [1], [3]
Description The interaction, between human Cytochrome P450 2C9 and Sulfatase from Parabacteroides johnsonii which collectively metabolize the drug Estrone sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-sulF interaction [1], [4]
Description The interaction, between human Cytochrome P450 3A4 and Sulfatase from Parabacteroides johnsonii which collectively metabolize the drug Estrone sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Tyrosine-protein phosphatase STS1/TULA2 (UBASH3B) Click to Show/Hide the Cometabolization Info
DME ID DME0430 DME Info
Uniprot ID
UBS3B_HUMAN
Interaction Name UBASH3B-sulF interaction [1], [5]
Description The interaction, between human Tyrosine-protein phosphatase STS1/TULA2 and Sulfatase from Parabacteroides johnsonii which collectively metabolize the drug Estrone sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Parabacteroides pacaensis sp. nov. and Parabacteroides provencensis sp. nov., two new species identified from human gut microbiota. New Microbes New Infect. 2020 Jan 7;34:100642.
2 Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):551-8.
3 Pharmacogenomics of CYP2C9: functional and clinical considerations. J Pers Med. 2017 Dec 28;8(1).
4 Estrogen regulation of the cytochrome P450 3A subfamily in humans. J Pharmacol Exp Ther. 2004 Nov;311(2):728-35.
5 Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism. Mol Cell Endocrinol. 2011 Jul 4;340(2):154-60.

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