General Information of DME (ID: DMEN072)
DME Name	Glutathione S-transferase (GST), .
Gene Name	GST
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs:          2 Drugs
Troglitazone	Drug Info	Approved	Diabetes mellitus	ICD11: 5A10	[1]
Ethacrynate sodium	Drug Info	Approved	Essential hypertension	ICD11: BA00	[2]
Drugs in Phase 3 Clinical Trial			Click to Show/Hide the Full List of Drugs:          1 Drugs
PG-490	Drug Info	Phase 3	Diabetes mellitus	ICD11: 5A10	[3]
Drugs in Phase 2 Clinical Trial			Click to Show/Hide the Full List of Drugs:          1 Drugs
BP-12941	Drug Info	Phase 2	Prostate cancer	ICD11: 2C82	[4]

Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF MR009897 Azathioprine 6-mercaptopurine Unclear - Non-enzymaticreduction Azathioprine [5] MR010547 Batabulin T138067-GSH Conjugation - Conjugation Batabulin [6] MR007328 BP-12941 Glutathione conjugation Unclear - Unclear BP-12941 [4] MR007231 Glyceryl trinitrate Nitrite Unclear - Unclear Glyceryl trinitrate [7] MR010452 Oprozomib Oprozomib Metabolite M4 Unclear - Unclear Oprozomib [8] MR006399 Hydroxytriptolide Hydroxytriptolide glutathione Conjugation - Conjugation PG-490 [3] MR002277 Nitroso-sulfamethoxazole Sulfamethoxazole GSH conjugate Unclear - Unclear Sulfamethoxazole [9] MR006993 3'-Oxohexobarbitall Hexobarbital glutathione conjugate derivative Conjugation - Glutathione conjugation VA-10872 [9] ⏷ Show the Full List of 8 MR(s)

References
1	Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects. Drug Des Devel Ther. 2022 Nov 8;16:3865-3876. doi: 10.2147/DDDT.S387508.
2	Ethacrynic Acid: A Promising Candidate for Drug Repurposing as an Anticancer Agent
3	Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154.
4	Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. AAPS J. 2014 Jul;16(4):705-13.
5	Gut Microbiota Metabolism of Azathioprine: A New Hallmark for Personalized Drug-Targeted Therapy of Chronic Inflammatory Bowel Disease
6	Glutathione S-transferase metabolism of the antineoplastic pentafluorophenylsulfonamide in tissue culture and mice
7	Nitroglycerin metabolism in vascular tissue: role of glutathione S-transferases and relationship between NO. and NO2- formation
8	In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s
9	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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