Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN146)
DME Name Aldehyde dehydrogenase family 1 member A3 (ALDH1A3), Homo sapiens
Gene Name ALDH1A3
UniProt ID
AL1A3_HUMAN
EC Number    EC: 1.2.1.36     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.2.1.36
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
Structure
5FHZ ; 6S6W ; 6TE5 ; 6TGW ; 6TRY ; 7A6Q ; 7QK7 ; 7QK8 ; 7QK9
Function Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) . High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity . Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity).
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Beta carotene
 Drug Info Approved Vitamin deficiency ICD11: 5B55 [1]
Cyclobenzaprine
 Drug Info Approved Depression ICD11: 6A71 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005738 Dihydroretinol Dihydroretinoic acid Unclear - Unclear Beta carotene [1]
MR005731 Retinal Retinoic acid Unclear - Unclear Beta carotene [1]
MR012903 Aldophosphamide Carboxyphosphamide Unclear - Unclear Cyclobenzaprine [3]
References
1 #NAME?
2 The KEGG resource for deciphering the genome
3 U. S. FDA Label -Cyclobenzaprine

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