Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN284)
DME Name Dihydropteridine reductase (QDPR), Homo sapiens
Gene Name QDPR
UniProt ID
DHPR_HUMAN
EC Number    EC: 1.5.1.34     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.34
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSF
TEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSH
LATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAV
LPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELT
PAYF
Structure
1HDR
Function Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Tetrahydrobiopterin
 Drug Info Investigative Vitamin deficiency ICD11: 5B55 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005898 qBH2(dihydrobiopterin quinoid) Tetrahydrobiopterin Unclear - Unclear Tetrahydrobiopterin [1]
References
1 Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.