Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN308)
DME Name Putative NAD(P)H nitroreductase YfkO (yfkO), Bacillus subtilis
Gene Name yfkO
UniProt ID
YFKO_BACSU
EC Number    EC: 1.-.-.-     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxidoreductase
Oxidoreductase
EC: 1.-.-.-
Lineage    Species: Bacillus subtilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Bacillus subtilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPSSLGLEPWKFVVVQNPE
FREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKRHLKEVKQMPQDVYEGYLS
KTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQIGVDSCPIEGFQYDHIHRIL
EEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVVKWV
Full List of Drug(s) Metabolized by This DME
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
CBL-954
 Drug Info Discontinued Hepatocellular carcinoma ICD11: 2C12 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005922 CBL-954 4-NHOH Unclear - Unclear CBL-954 [1]
References
1 uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954

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