Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005922)
Formula	yfkO
	Reactant	CBL-954	Product	4-NHOH
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Putative NAD(P)H nitroreductase YfkO (yfkO)				DME Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005921	CBL-954	2-NHOH	Unclear	CBL-954	[1]
MR005923	CBL-954	The hydroxylamine metabolite	Unclear	CBL-954	[2]

References
1	uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954
2	Bystander or no bystander for gene directed enzyme prodrug therapy

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