Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN721)
DME Name Guanylate kinase (GUK1), Homo sapiens
Gene Name GUK1
UniProt ID
KGUA_HUMAN
EC Number    EC: 2.7.4.8     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.4.8
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV
MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI
SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE
LKEALSEEIKKAQRTGA
Structure
6NUI
Function Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) . Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors . In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine .
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Valaciclovir
 Drug Info Approved Virus infection ICD11: 1A24-1D9Z [1]
Valacyclovir Hydrochloride
 Drug Info Approved Herpes simplex virus infection ICD11: 1F00 [2]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Amdoxovir
 Drug Info Phase 2 Hepatitis B virus infection ICD11: 1E50-1E51 [3]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008548 DXG-MP DXG-DP Unclear - Unclear Amdoxovir [3]
References
1 DrugBank(Pharmacology-Metabolism):Valaciclovir
2 DrugBank(Pharmacology-Metabolism):Valacyclovir Hydrochloride
3 Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases

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