Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017378)
DM Name	DXG-DP

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Guanylate kinase (GUK1)	DMEN721	DXG-MP	Unclear - Unclear	Amdoxovir	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
3-phosphoglycerate Kinase (3-PGK)	DMEN772	DXG-triphosphate (DXG-TP)	Conjugation - Phosphorylation	Amdoxovir	[1]
creatine kinase (CKB)	DMEN771	DXG-triphosphate (DXG-TP)	Conjugation - Phosphorylation	Amdoxovir	[1]
Nucleoside diphosphate kinase (NME4)	DMEN006	DXG-triphosphate (DXG-TP)	Conjugation - Phosphorylation	Amdoxovir	[1]
pyruvate kinase M2 (PKM2)	DMEN373	DXG-triphosphate (DXG-TP)	Conjugation - Phosphorylation	Amdoxovir	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Amdoxovir		DR4678	Phase 2		Hepatitis B virus infection

References
1	Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases

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