Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DMEN854) | |||||
|---|---|---|---|---|---|
| DME Name | Beta-glucuronidase (Gusb), Rattus norvegicus | ||||
| Gene Name | Gusb | ||||
| UniProt ID | |||||
| EC Number | EC: 3.2.1.31 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Sequence |
MSPRRSVCWFVLGQLLCSCAVALQGGMLFPKETPSRELKVLDGLWSFRADYSNNRLQGFE
KQWYRQPLRESGPTLDMPVPSSFNDITQEAELRNFIGWVWYEREAVLPQRWTQDTDRRVV LRINSAHYYAVVWVNGIHVVEHEGGHLPFEADITKLVQSGPLTTFRVTIAINNTLTPYTL PPGTIVYKTDPSMYPKGYFVQDISFDFFNYAGLHRSVVLYTTPTTYIDDITVTTDVDRDV GLVNYWISVQGSDHFQLEVRLLDEDGKIVARGTGNEGQLKVPRAHLWWPYLMHEHPAYLY SLEVTMTTPESVSDFYTLPVGIRTVAVTKSKFLINGKPFYFQGVNKHEDSDIRGRGFDWP LLIKDFNLLRWLGANSFRTSHYPYSEEVLQLCDRYGIVVIDECPGVGIVLPQSFGNVSLR HHLEVMDELVRRDKNHPAVVMWSVANEPVSSLKPAGYYFKTLIAHTKALDPTRPVTFVSN TRYDADMGAPYVDVICVNSYLSWYHDYGHLEVIQLQLTSQFENWYKMYQKPIIQSEYGAD AVSGLHEDPPRMFSEEYQTALLENYHLILDEKRKEYVIGELIWNFADFMTNQSPLRVTGN KKGIFTRQRNPKMAAFILRERYWRIANETRGYGSVPRTQCMGSRPFTF |
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| Function | Plays an important role in the degradation of dermatan and keratan sulfates. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 2 Drugs | ||||
Budipine |
Drug Info | Approved | Migraine | ICD11: 8A80 | [1] |
Mephentermine |
Drug Info | Approved | Essential hypertension | ICD11: BA00 | [2] |
| References | |||||
|---|---|---|---|---|---|
| 1 | The metabolic fate of the anti-parkinsonian drug budipine in rats | ||||
| 2 | Intestinal metabolism of mephentermine and its biliary metabolites in male Wistar rats | ||||
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