Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5249)
Drug Name
Mephentermine
Synonyms
Mefenterdrin; Mefentermin; Mefentermina; Mephenterdrine; Mephenterdrinum; Mephenterminum; Mephetedrine; Mephine; Vialin; Wyamine; Wyfentermina; Mefentermina [INN-Spanish]; Mephentermine (INN); Mephentermine [INN:BAN]; Mephenterminum [INN-Latin]; N-Methylphentermine; WY-585; Mephentermine Sulfate (2:1); N,alpha,alpha-Trimethylbenzeneethanamine; N,alpha,alpha-Trimethylphenethylamine; Omega-Phenyl-tert-butyl-methylamine; N-Methyl-omega-phenyl-t-butylamine; N-Methyl-omega-phenyl-tert-butylamine; N,2-dimethyl-1-phenylpropan-2-amine; 2-Methyl-2-methylamino-1-phenylpropane; 2-Methylamino-2-methyl-1-phenylpropane
Indication Essential hypertension [ICD11: BA00] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 163.26 Topological Polar Surface Area 12
Heavy Atom Count 12 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
3677
ChEBI ID
CHEBI:6755
CAS Number
100-92-5
TTD Drug ID
D0G1OZ
Formula
C11H17N
Canonical SMILES
CC(C)(CC1=CC=CC=C1)NC
InChI
InChI=1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3
InChIKey
RXQCGGRTAILOIN-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
N-demethyl-MP DM016946 N. A. Oxidation - N-demethylation 1 [2]
N-Hydroxy-MP DM015232
173639
Oxidation - N-hydroxylation 1 [2]
Phentermine DM014874
4771
Oxidation - Oxidative dealkylation 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007800 Mephentermine N-Hydroxy-MP Oxidation - N-hydroxylation Unclear [2]
MR007801 Mephentermine N-demethyl-MP Oxidation - N-demethylation Unclear [2]
MR007802 Mephentermine Phentermine Oxidation - Oxidative dealkylation Unclear [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Beta-glucuronidase (Gusb) DMEN854 Rattus norvegicus
BGLR_RAT
3.2.1.31
[2]
Cytochrome P450 (CYP) DMEN060 . Not Available Not Available [3]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Intestinal metabolism of mephentermine and its biliary metabolites in male Wistar rats
3 Metabolism of mephentermine and its derivatives by the microsomal fraction from male Wistar rat livers
4 The influence of diuretics on the excretion and metabolism of doping agents - I. Mephentermine

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