Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1043)
DME Name Beta-glucosidase (bglA), Malassezia furfur
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BGK71_01895
Gene Name bglA
UniProt ID
A0A249DCH3_LACRH
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Malassezia furfur     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Basidiomycota
Class: Malasseziomycetes
Order: Malasseziales
Family: Malasseziaceae
Genus: Malassezia
Species: Malassezia furfur
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MTQQQLYTPKGFPKNFLWGGAIAANQAEGAWQTDGRGPSQADIMLLPEKYSRLGSFGEHV
TRADIERALADKSGNYPRRRGIDFFHTYDSDLDLMKEMGFNTFRTSFSWSRIFPNGDEKE
PNEKGLKFYDKLIQKMLDLDITPVMTISHYEMPLNLITKYGGWENPEMINFFNRFAQVLL
DRYHDKVKYWIVFNQVNDVYGWGEFAGLGILKENQPNEKQAKFQAVHHQFIANAQTVKYG
HQIDNDIKIGMMLGLTNVYPASTKPQDVMATYKRWNKDTFFFSDVLARGEYPGYMLRYFE
DNNIQLSIDQKELDLIKNNPVDFIAFSYYSSSLISADTPDSLLPNPELEESIWGWSFDPI
GFRYGFNVLWDRYHLPLFVAENGLGALDTVEDNKIHDAYRIKYLKAHIKQMKEAIKDGVH
IFGYAAWGPIDIVSYSQAEMSKRYGFVYVDLDDKGNGTGKRIRKDSFYWYQKVIESNGDQ
I
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-0075455
 Drug Info Phase 2/3 Diabetes mellitus ICD11: 5A10 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Esculin
 Drug Info Investigative Appendicitis ICD11: DB10 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR006509 AS-35335 Leucocyanidin Hydrolysis - Hydrolysis AS-35335 [1]
MR006512 AS-35335 Leucocyanidin Hydrolysis - Hydrolysis BRN-0075455 [1]
MR007439 DB-041901 Sennidin-8-monoglucoside Hydrolysis - Hydrolysis DB-041901 [3]
MR007441 Sennidins Rheinanthrone Unclear - Unclear DB-041901 [4]
References
1 Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100.
2 A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.
3 The action of sennosides and related compounds on human colon and rectum
4 Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract

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