Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1057)
DME Name Catechol-2,3-dioxygenase (caD), Bacillus pumilus
Synonyms Catechol dioxygenase; Catechol 2,3-dioxygenase; caD; cado; DZB84_00060
Gene Name DZB84_00060
UniProt ID
A0A371SLU3_9BACI
EC Number    EC: 1.13.11.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.2
Lineage    Species: Bacillus pumilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus pumilus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSNFDVAQLAHVELYSPKPEETLKFFTDYLGLQISAREGQSVYLRAYEDFYHHTLKITEA
KEAGMAHTAWRASSEAALYQRVQSLEKSGYGKGWIEGDLGHGAAYQFQTPDGHNMEILWN
VEYYRAPEDQKTMLKSRPQKRPNIGIPARRLDHINLMCGNVTQNKQFMADELGFKLRENI
IMNDGAEMGAWMSVSPLVHEIALMGDQSGEKGRFHHVAYWYGYPQHLMDLADLLVENGIE
IEAGPGKHGISQAYFMYVFEPGGNRVELFGDSGYLILDPDWKTITWKEEELDKGIIWYGS
PLPQEYFIYGTPDRSSVKVK
Function This enzyme initiates the meta-cleavage pathway of catechol degradation and requires FeII.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Gemfibrozil
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
References
1 Genomic, proteomic, and metabolite characterization of gemfibrozil-degrading organism Bacillus sp. GeD10. Environ Sci Technol. 2016 Jan 19;50(2):744-55.

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