Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1080)
DME Name Azoreductase (azoR), Streptococcus salivarius
Synonyms Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; Flavin reductase; NAD(P)H-dependent oxidoreductase; NADPH azoreductase; azoR; A6J87_06095; CKU37_01320; CQA85_07565; D8867_01950; DL07_01170; DWV94_10025; DWY30_01550; DWZ07_06240; FBF48_06605; NCTC8618_04344; azr_2; azr_4
Gene Name azr_2
UniProt ID
A0A074IU04_STRSL
Gene ID
29398535
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Streptococcus salivarius     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus salivarius
Subspecies: Streptococcus salivarius K12
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKFVGLVGANYDQSYNRKLLEFIRRHFKIKFELEVLEIDEVPMFNQDEKWDESFQLRLLN
NKITRADGVIIATPEHNHTISAALKSVLEWLSFEVHPFENKPVMIVGASYYDQGTSRAQV
HLRKILEAPGVNAYTLPGNEFLLGKAKEAFDLEGNITNEGTINFLEQCLDNFIQYVGVVS
KLKKPKPIEPEDLDCNNPIATTVTEVDPDDPEWVEKVAEITGAVSGDTYVKLDHGILTVN
QIDMFLKAMPFELTYADDNNQFLYYNNAHQDPDTMFAKRVPPQSGSRMSTVHGSLPPARM
KNVEWVIGTLRNGNQEYVRTIVPGSPEGVINTHNYQAMYYDDGSYAGINEIVFNFKPWLD
WYLETTGQRLVGGSGPFAPAAASHGGSDATSGASDAGGHGGDAAPAADATSGASSY
Function This enzyme can reduce other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
References
1 The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7.

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