Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1116)
DME Name D-Lactate dehydrogenase (ldhA), Megasphaera elsdenii
Synonyms Glycolate dehydrogenase; D-lactate ferricytochrome C oxidoreductase; Fermentative lactate dehydrogenase; D-LDH; Q058_03541; ldhA
Gene Name ldhA
UniProt ID
A0A1C7BXR3_PSEAI
EC Number    EC: 1.1.1.28     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.28
Lineage    Species: Megasphaera elsdenii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Veillonellales
Family: Veillonellaceae
Genus: Megasphaera
Species: Megasphaera elsdenii
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MRILFFSSQAYDSESFQASNHRHGFELHFQQAHLQADTAVLAQGFEVVCAFVNDDLSRPV
LERLAAGGTRLVALRSAGYNHVDLAAAEALGLPVVHVPAYSPHAVAEHAVGLILTLNRRL
HRAYNRTREGDFSLHGLTGFDLHGKRVGVIGTGQIGETFARIMTGFGCELLAYDPYPNPR
IQALGGRYLALDALLAESDIVSLHCPLTADTRHLIDAQRLATMKPGAMLINTGRGALVNA
AALIEALKSGQLGYLGLDVYEEEADIFFEDRSDQPLQDDVLARLLSFPNVVVTAHQAFLT
REALAAIADTTLDNIAAWQDGTPRNRVRA
Function This enzyme has D-lactate dehydrogenase activity.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Methylglyoxal
 Drug Info Investigative Alzheimer disease ICD11: 8A20 [1]
D-glucose
 Drug Info Investigative Discovery agent ICD: N.A. [2], [3]
References
1 Cells producing their own nemesis: understanding methylglyoxal metabolism
2 Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate. Appl Environ Microbiol. 1993 Jan;59(1):255-9.
3 hole-Genome sequence of a Megasphaera elsdenii strain isolated from the gut of a healthy Indian adult subject. Genome Announc. 2017 Oct 19;5(42):e01033-17.

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