Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1142)
DME Name Aminoglycoside O-phosphotransferase (aphA6), Providencia stuartii
Synonyms Aminoglycoside 3'-phosphotransferase; Kanamycin kinase, type VI; Neomycin-kanamycin phosphotransferase type VI; APH(3')VI; AphA6; aphA-6; aphA6
Gene Name aphA6
UniProt ID
G9FRK8_PROST
EC Number    EC: 2.7.1.95     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.95
Lineage    Species: Providencia stuartii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Providencia
Species: Providencia stuartii
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
GNSVLEPNKIGQSPSDVYSFNRNNETFFLKRSSTLYTETTYSVSREAKMLSWLSDKLKVP
ELIMTFQDEQFEFMITKAINAKPISALFLTEQELLAIYKETLNQLNAVAIIDCPFISSID
HRLKESKFFIDNQLLDEIDQDDLDAELWGDHKTYISLWNELNETRVEERLVFSHGDITDS
NIFIDKSGEIYFLDLGRAGLADEFVDISFVERCLREDVSEETAKIFLKHLKNDRPDKR
Function This enzyme acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Plazomicin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
References
1 Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. ACS Infect Dis. 2018 Jun 8;4(6):980-987.

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