Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1142)
DME Name Aminoglycoside O-phosphotransferase (aphA6), Providencia stuartii DME Info
UniProt ID
G9FRK8_PROST
EC Number    EC: 2.7.1.95     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.95
Lineage    Species: Providencia stuartii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Providencia
Species: Providencia stuartii
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Lactotransferrin truncated peptide HLP2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03575   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lactotransferrin truncated peptide HLP2 inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Providencia stuartii (MIC = 110 microM) [1]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Amikacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00122   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amikacin inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Providencia stuartii [2]
                              Ceftazidime Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00237   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ceftazidime inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Providencia stuartii [2]
                              Ciprofloxacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00349   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ciprofloxacin inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Providencia stuartii [2]
References
1 Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111. Infect Immun. 1998 Jun;66(6):2434-40.
2 Effect of ceftazidime, amikacin and ciprofloxacin on biofilm formation by some enterobacterial clinical isolates. Chemotherapy. 2004 Nov;50(5):255-9.

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