Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1153)
DME Name Histidine decarboxylase (hdcA), Lactobacillus reuteri
Synonyms Histidine decarboxylase proenzyme; hdcA; HDC; DKZ26_01060
Gene Name hdcA
UniProt ID
A0A0K6GJ74_LACRE
EC Number    EC: 4.1.1.22     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.22
Lineage    Species: Lactobacillus reuteri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus reuteri
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSELDTKLHKLGVDRIAISPYKQWSRGYMEPGNIGNGYVTGLKVDAGVRDKTDDEVLDGI
VSYDRAETKNAYIGQINMTTASSFTGPQGHCIGYDLLRNPEVDTAEPLFTVKQWDGSELP
IYDAKPLQDSLVEYFGTNNNRRHYPAPGSFIVCANKGVTAERPMNDSDMKPGQGYGVWSA
IALSFAKDPAKDSSMFIEDAGVWETPNEDELIEYLKGRRKAIAKSIAECGQDANTSFKGS
WIGFAHAMMEPGQIGNAITVAPYISMPVDSIPGGSILTPDTDMDIMENLTMPEWLDKMEY
KSLTANGAIKY
Function This enzyme catalyzes the decarboxylation of histidine to form histamine.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
L-histidine
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005377 L-histidine Histamine Unclear - Unclear L-histidine [2], [3], [4]
References
1 Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS One. 2012;7(2):e31951.
2 Biomarkers of PEGylated Liposomal Doxorubicin-Induced Hypersensitivity Reaction in Breast Cancer Patients Based on Metabolomics
3 Measurement and characterization of histamine and methylhistamine in human urine under histamine-rich and histamine-poor diets
4 Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

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