Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1240)
DME Name Hyaluronate lyase (hyaL), Streptobacillus moniliformis
Synonyms Alginate lyase; Poly-beta-D-glucuronate lyase; Endolytic polysaccharide lyase; Multifunctional polysaccharide lyase; Polysaccharide lyase; PL; Smon_0117
Gene Name hyaL
UniProt ID
D1AWD4_STRM9
Gene ID
29673833
EC Number    EC: 4.2.2.1     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-oxygen lyase
Polysaccharide-lyase
EC: 4.2.2.1
Lineage    Species: Streptobacillus moniliformis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Leptotrichiaceae
Genus: Streptobacillus
Species: Streptobacillus moniliformis
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human blood.
Sequence
MYELLLKRREYLIGNFKDLPLNKRKQIEEIQEKNIEKLEYLENLNIAEVKLKYNNILELA
KAYNQVGNVRYRDEKIKVIILKTLKLLRITYYNLSSVEKVNWWQWEIGIPLLLNDIFILM
NEKDFDFEKEENLKTSIYFQKDPRYSGNNPVATHPSKKPFRISTGGNRVDTVKVSLFRSI
LLNNEEELKLALNSLPEVWKCREKINRIETDTQRDGFYNDGSFIQHGSLAYNGTYGNVLL
QGIGEILYVIGDSKYLKYLGDIYSLKDIILNSYKPFMYKGSFPDMLNGRAITRENSSDKT
IGHMLLNSIMLISCGLNDEELKNLVASEILKYEDYSYFDKELSPFMYDLVKKNIHNRKKE
EYGKIIKVSNIMNRVFIKDDKKAIAIAGHSENISNYESINGENTKGWYTGDGMIYLYTSD
VTYTNYWNNSDTRYMSGTTEVYEDLNGINTSQILNVNMSSAKIVKAIEKDNKMIFFMEFE
NHNKSLKMYKSYVYTGKKLICLNTNIDTKEKIYTTIDNRLYKEKPKIVMEDKRILINDLI
FNIITDHKFNFDIKESEFGYFVKIWIEHKYNENLYYEIIFEYDDKTSLIEDNKENIIIRN
GNEKYLINTKEKEVLRFE
Function This enzyme catalyzes the degradation of hyaluronan by a beta-elimination reaction and it also acts on chondroitin.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
Chondroitin sulfate
 Drug Info Phase 4 Osteoarthritis ICD11: FA00 [1], [2]
Hyaluronan
 Drug Info Phase 4 Osteoarthritis ICD11: FA00 [1]
References
1 A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069.
2 A case of Streptobacillus moniliformis infection with cutaneous leukocytoclastic vasculitis. Acta Med Okayama. 2016 Oct;70(5):377-381. Case Reports

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