Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1545)
DME Name Sucrose phosphorylase (Spase), Bifidobacterium longum
Synonyms Sucrose glucosyltransferase; Glucosyltransferase-A; SPase; GTF-A; SP; treY; BBG7_0104; CE169_10215
Gene Name treY
UniProt ID
A0A0M4N1J6_BIFLN
EC Number    EC: 2.4.1.7     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.7
Lineage    Species: Bifidobacterium longum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium longum
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MKNKVQLITYADRLGDGTLSSMTDILRTRFDGVYDGVHILPFFTPFDGADAGFDPIDHTK
VDERLGSWDDVAELSKTHNIMVDAIVNHMSWESKQFQDVLEKGEESEYYPMFLTMSSVFP
NGATEEDLAGIYRPRPGLPFTHYNLGGKTRLVWVSFTPQQVDIDTDSAKGWEYLMSIFDQ
MAASHVRYIRLDAVGYGAKEAGTSCFMTPKTFKLISRLREEGVKRGLEILIEVHSYYKKQ
VEIASKVDRVYDFALPPLLLHSLFTGHVEPVAHWTEIRPNNAVTVLDTHDGIGVIDIGSD
QLDRSLKGLVPDEDVDNLVNTIHANTHGESQAATGAAASNLDLYQVNSTYYSALGCNDQH
YLAARAVQFFLPGVPQVYYVGALAGRNDMELLRRTNNGRDINRHYYSTAEIDENLERPVV
KALNALAKFRNELSAFDGEFSYEVDGDTSITFRWTAADGASTAALTFEPGRGLGTDNATP
VASLAWSDAAGDHETHDLLANPPIADID
Function This enzyme catalyzes the conversion of sucrose to D-fructose and alpha-D-glucose-1-phosphate.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Kestose
 Drug Info Preclinical Atopic dermatitis ICD11: EA80 [1]
Sucrose
 Drug Info Investigative Prematurity retinopathy ICD11: 9B71 [1]
References
1 Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298.

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