Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1617)
DME Name Oxygen-insensitive NADPH nitroreductase B (nfsB), Salmonella enterica
Synonyms Oxygen-insensitive NAD(P)H nitroreductase B; Dihydropteridine reductase; FMN-dependent nitroreductase; STM0578; pnrB
Gene Name nfsB
UniProt ID
NFSB_SALTY
Gene ID
1252098
EC Number    EC: 1.5.1.34     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.34
Lineage    Species: Salmonella enterica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium TA100
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MDIVSVALQRYSTKAFDPSKKLTAEEADKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV
AKSAAGNYTFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEDADGRFATPEAKAANDKG
RRFFADMHRVSLKDDHQWMAKQVYLNVGNFLLGVAAMGLDAVPIEGFDAEVLDAEFGLKE
KGYTSLVVVPVGHHSVEDFNAGLPKSRLPLETTLTEV
Structure
3HZN
Pathway Microbial metabolism in diverse environments (stm01120 )
Nitrotoluene degradation (stm00633 )
Function This enzyme can reduce a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. And it also can reduce nitrofurazone.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
AI3-23606
 Drug Info Phase 1 Trypanosomiasis ICD11: 1F51 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
Nitroimidazole
 Drug Info Investigative Discovery agent ICD: N.A. [1]
CL-205086
 Drug Info Investigative Amebiasis ICD11: 1A36 [1]
GW9662
 Drug Info Investigative Breast cancer ICD11: 2C60 [2]
References
1 Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8.
2 Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chem Biol Interact. 2012 Apr 15;197(1):16-22.

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