Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1719)
DME Name Alpha-galactosidase (melA), Streptococcus thermophilus
Synonyms Alpha-D-galactoside galactohydrolase; 1,6-alpha-D-galactoside galactohydrolase; Galactosidase alpha; Ag-I; Ag-II; Aga-F78; Aga-Y; AgaA; agaAJB13; AgaB; AgaI; BGNBKFLM_00010; agaSK
Gene Name agaSK
UniProt ID
A0A564RX90_STRTR
EC Number    EC: 3.2.1.22     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.22
Lineage    Species: Streptococcus thermophilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus thermophilus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSITINKNYYYINSKELSLIIEEREGDLLLRHLGRKITNYHGSNAVNERDHAFSGQLNPD
IRTYSYDTQRQVLGLHGLGDFRQPSLKIQHGVSDVTRFEFSKAEVVKGISLESKLPYPHS
LENAETLIFTLVDKVADLELKLYYTVVEDNNTIVTYSEVINNSNQAVVIHRALSAMADVP
ARDYDVVTLQGAYAREKTVRRQRVEQGIFKVGSNRGASGHAQTPALILCDHEASEGAGEA
LAFQLMYSGNFQTFVQKSQINEVRVAIGIEDENFTWELASNESFETPVALITYSHQGLTG
VSQESQAFVTDYIIPKQFAHEERPILLNNWEATYFDFEKEKLLELAEDAKQVGAELFVLD
DGWFGNRFDDNRALGDWFVNEEKLGGPLQDLIEKVHAKGLKFGLWFEPEMISVDSDLYRK
HPDWAIQVPNYGHTYSRNQLVLNLANPDVVTYLKDVLDKILTDNAIDYVKWDYNRNITNI
GNGANYLESQMLSHQYMLGLYDLVEFLTSKHENILFESCSGGGGRNDLGMMRYFPQVWAS
DNTDAIARLTIQYGSSYLYPTISMGAHVSAVPNHQLERTTPLETRGDVAMMGNLGYELDL
TSLTQEEKESIAAQIAHYKDIRPVVQFGQQYRLINPEAGSNEAAVQFNYENKVLATYVRI
LSTIETVETTLKLKNLDQDANYMLQGTGQVYSGAELMYAGITVVLPQGDFLSKQFYFVKV
D
Function This enzyme hydrolyzes alpha-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Raffinose
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Melibiose
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Use of an alpha-galactosidase gene as a food-grade selection marker for Streptococcus thermophilus. J Dairy Sci. 2005 Jul;88(7):2341-7.

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