Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2021)
DME Name Carbapenemase (cphA), Achromobacter xylosoxidans
Synonyms Versatile beta-lactamase; Versatile hydrolytic beta-lactamase; Beta-lactamase II; Carbapenem-hydrolyzing metallo-beta-lactamase; Metallo-beta-lactamase type 2b; Metallo-beta-lactamase type IIb; axc
Gene Name axc
UniProt ID
A0A3G1JAD7_ALCXX
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Achromobacter xylosoxidans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Achromobacter
Species: Achromobacter xylosoxidans
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human stomach.
Sequence
MLTRRTFIASAVLAGWIPALAHARTDKKTRWTRESLAAFQQGLAQVEAASRGRLGVALLD
VGSGQAAGYRADERFLMLSSFKTLSAAYVLARADRGEDQLSRRIPITDADVREYSPVTRL
HVGPRGMTLAELCEATITTSDNAAVNLMHKSYGGPQALTRYLRSLGDTVTRHDRYEPELN
RPHPSEPQDTTTPQAMARTLDTLLFGDALKPQSRQQLQSWLLANTTGGKRLRAGMPADWK
IGEKTGTYSKVGCNDAGFAQPPGAAPIIIAAYLETTAVPMEERDRCIAEVGRLVAALG
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Imipenem
 Drug Info Phase 4 Acute pancreatitis ICD11: DC31 [1]
References
1 Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans. Sci Rep. 2018 May 25;8(1):8181.

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